Pharmacotherapy of Depression
Comprehensive and state-of-the-art, the second edition of Pharmacotherapy of Depression offers major revisions of every chapter and the addition of new chapters by expert contributors. The first chapter reviews the neurobiology of depression, which lays t
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Domenic A. Ciraulo • Richard Irwin Shader Editors
Pharmacotherapy of Depression Second Edition
Editors Domenic A. Ciraulo Boston University School of Medicine Boston, MA USA
Richard Irwin Shader Tufts University School of Medicine Boston, MA USA
ISBN 978-1-60327-434-0 e-ISBN 978-1-60327-435-7 DOI 10.1007/978-1-60327-435-7 Springer New York Dordrecht Heidelberg London © Springer Science+Business Media, LLC 2004, 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface
The first edition of the Pharmacotherapy of Depression was published in 2004 and the editors wish to express appreciation for the positive reviews of that book. The second edition is similar in organization to the first, but has undergone major revisions of every chapter, the addition of new chapters, and expansion of our expert contributors. We have tried to provide sufficient depth in our reviews of the research literature to support our clinical recommendations without burdening the reader with information that is not of clinical importance for the prescriber. The first chapter reviews the neurobiology of depression, which lays the groundwork for understanding the mechanisms of action of antidepressants. In the next chapter, we review the general principles guiding the diagnosis and medication treatment of unipolar depression. The clinical pharmacology of antidepressants is reviewed in some detail, supplemented by tables that provide information on dosing, indications, and metabolism. Augmentation strategies are reviewed, including the use of nontraditional agents. The chapters that follow address the use of antidepressants in special populations, such as the elderly and depressed individuals with psychosis, bipolar disorder, substance abuse, and posttraumatic stress disorder. The complex issues involving the diagnosis and treatment of depression during pregnancy are thoroughly reviewed in Chap
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