Birth, Life and Death of Dopaminergic Neurons in the Substantia Nigra
This book provides a unique and timely multidisciplinary synthesis of our current knowledge of the anatomy, pharmacology, physiology and pathology of the substantia nigra pars compacta (SNc) dopaminergic neurons. The single chapters, written by top scient
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Editors Prof. Dr. Giuseppe Di Giovanni Universita` di Palermo Dipartimento di Medicina Sperimentale, Sezione di Fisiologia Umana, ‘‘G. Pagano’’, Universita´ degli Studi di Palermo, Palermo, Italy. Corso Tukory, 129 90134 Palermo Italy [email protected]
Dr. Vincenzo Di Matteo Istituto di Ricerche Farmacologiche Mario Negri Consorzio Mario Negri Sud Via Nazionale, 8 66030 Santa Maria Imbaro (CH) Italy [email protected]
Dr. Ennio Esposito Istituto di Ricerche Farmacologiche Mario Negri Consorzio Mario Negri Sud Via Nazionale, 8 66030 Santa Maria Imbaro (CH) Italy [email protected]
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machines or similar means, and storage in data banks. Product Liability: The publisher can give no guarantee for all the information contained in this book. This does also refer to information about drug dosage and application thereof. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. # 2009 Springer-Verlag/Wien Printed in Germany SpringerWienNewYork is part of Springer Science+Business Media springer.at Typesetting: SPI, Pondicherry, India Printed on acid-free and chlorine-free bleached paper SPIN: 12185931 With 22 (partly coloured) Figures Library of Congress Control Number: 2009926021
ISSN 0303-6975 ISBN 978-3-211-92659-8 e-ISBN 978-3-211-92660-4 DOI: 10.1007/978-3-211-92660-4 Springer Wien New York
To Giulio Di Giovanni, who suffered from Parkinson’s disease
Preface
The aim of this supplement of The Journal of Neural Transmission is to provide the reader with a unique and timely multidisciplinary synthesis of our current knowledge of the anatomy, pharmacology, physiology, and pathology of the substantia nigra pars compacta dopaminergic neurons. This is most probably one of the most investigated groups of neurons in scientific literature since the discovery of dopamine deficiency in Parkinson’s disease by Hornykievicz and his collaborator Ehringer at the end of the 1950s. With this in mind, we offer as varied a picture as possible, by including exhaustive reviews as well as original research papers covering different points of view, together with different aspects of the life cycle of dopamine neurons from their birth to death. New evidence has recently emerged thanks to the development of new techniques in molecular biology, genetics, single-cell and membrane physiology, clinical neurology, and in vivo brain imaging. The selection starts by reviewing the ontogeny of nigrostriatal dopamine neurons. Thereafter, single chapters explore dopaminergic neuron functions from th
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