The Human Substantia Nigra and Ventral Tegmental Area A Neuroanatomi

This study on the human midbrain examines how specific neuroanatomical structures are involved in the aging process and in certain degenerative diseases of the nervous system.

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Editors F. Beck, Leicester W Hild, Galveston W Kriz, Heidelberg IE. Pauly, Little Rock Y Sano, Kyoto T.H. Schiebler, Wiirzburg

P.H.M.F. van Domburg H.I ten Donkelaar

The Human Substantia Nigra and Ventral Tegmental Area A Neuroanatomical Study with Notes on Aging and Aging Diseases

With 38 Figures

Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona

Dr. Peter Henricus Maria Franciscus van Domburg Departments of Anatomy/Embryology and Neurology Faculty of Medicine, University of Nijmegen P.O. Box 9101, NL-6500 HB Nijmegen Dr. Hendrik Jan ten Donkelaar Department of Anatomy and Embryology Faculty of Medicine, University of Nijmegen P.O. Box 9101, NL-6500 HB Nijmegen

ISBN-13: 978-3-540-52823-4 e-ISBN-13: 978-3-642-75846-1 DOl: 10.1007/ 978-3-642-75846-1 Library of Congress Cataloging-in-Publication Data Domburg, P.H.M.F. van (Peter Henricus Maria Franciscus), 1954The human substantia nigra and ventral tegmental area: a neuroanatomical study with notes on aging and aging diseases/ P.H.M.F. van Domburg, H.J. ten Donkelaar. p.cm.-(Advances in anatomy, embryology, and cell biology; vol. 121) Includes bibliographical references. Includes index. I. Substantia nigra. 2. Mesencephalic tegmentum. 3. Substantia nigra-Aging. 4. Mesencephalic tegmentum-Aging. I. Donkelaar, H.J. ten (Hendrik Jan), 1946II. Title. III. Series: Advances in anatomy, embryology, and cell biology; v. 121. [DNLM: I. Aging. 2. Basal Ganglia Diseases-pathology. 3. Substantia Nigra-anatomy & histology. 4. Tegmentum Mesencephali-anatomy & histology WI AD433K v. 121jWL 310 D667h QL80l.E67 vol. 121 [QP378.3] 574.4 s-dc20 [612.8'25] 90-10121

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© Springer-Verlag Berlin Heidelberg 1991 The use of general descriptive names, trade names, trade marks, etc. in this publication, even if the former are not especially identified, is not to be taken as a sign that such names, as understood by the Trade Marks and Merchandise Marks Act, may accordingly be used freely by anyone. Product Liability: The publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. Typesetting: Macmillan India Ltd, Bangalore 25, India 2121/3130-543210 - Printed on acid-free paper

Contents

1

Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

2

Materials and Techniques. . . . . . . . . . . . . . . . . . . . .

3