Bisphenol A exposure associated with all-cause mortality
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Bisphenol A exposure associated with all-cause mortality Higher levels of exposure to bisphenol A (BPA) are associated with a significantly increased risk of all-cause mortality, according to study results reported in JAMA Network Open, but not cardiovascular disease mortality or cancer mortality. The study included 3883 patients, ≥20 years of age, who participated in the USA’s National Health and Nutrition Examination Survey (NHANES) of civilian noninstitutionalised residents in 2003–2008. Their weighted mean age was 43.6 years, and there were 2032 women. Spot urine samples were provided for BPA level measurements; results were divided into tertiles, with median BPA levels of 0.7, 2.1 and 5.7 ng/mL, respectively. During 36 514 person-years of follow-up, there were 344 deaths. Compared with participants in the lowest tertile, those in the highest tertile had a significantly increased risk of all-cause mortality (adjusted hazard ratio [HR] 1.49; 95% CI 1.01, 2.19). There was no significant difference for those in the middle tertile (HR 1.10; 0.78, 1.55). Although participants in the highest tertile had an increased risk of cardiovascular disease death, the risk was not significant (HR 1.46; 0.67, 3.15); the authors note that this association "warrants further investigation". There was no increased risk of cancer mortality (HR 0.98; 0.40, 2.39). There were no apparent mortality differences by age, diet quality, obesity status, physical activity, race/ethnicity or sex. "Our findings may have major public health implications", note the authors, as "exposure to BPA is ubiquitous among humans". They add that "further studies are needed to replicate these findings in other populations and determine the underlying mechanisms". Bao W, et al. Association Between Bisphenol A Exposure and Risk of All-Cause and Cause-Specific Mortality in US Adults JAMA Network Open : 17 Aug 2020. Available from: URL: https://doi.org/10.1001/jamanetworkopen.2020.11620 803500220
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