Blunted cardiac output response to exercise in adolescents born preterm
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ORIGINAL ARTICLE
Blunted cardiac output response to exercise in adolescents born preterm Kristin Haraldsdottir1,2 · Andrew M. Watson2 · David F. Pegelow1 · Mari Palta4,7 · Laura H. Tetri1 · Taylor Levin1 · Melissa D. Brix1,5 · Ryan M. Centanni1,5 · Kara N. Goss1,3 · Marlowe M. Eldridge1,5,6 Received: 24 April 2020 / Accepted: 19 August 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose Premature birth is associated with lasting effects, including lower exercise capacity and pulmonary function, and is acknowledged as a risk factor for cardiovascular disease. The aim was to evaluate factors affecting exercise capacity in adolescents born preterm, including the cardiovascular and pulmonary responses to exercise, activity level and strength. Methods 21 preterm-born and 20 term-born adolescents (age 12–14 years) underwent strength and maximal exercise testing with thoracic bioimpedance monitoring. Baseline variables were compared between groups and ANCOVA was used to compare heart rate, cardiac output (Q) and stroke volume (SV) during exercise between groups while adjusting for body surface area. Results Preterm-borns had lower maximal aerobic capacity than term-borns (2.0 ± 0.5 vs. 2.5 ± 0.5 L/min, p = 0.01) and lower maximal power (124 ± 26 vs. 153 ± 33 watts, p
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