BNCT for Advanced or Recurrent Head and Neck Cancer
The therapeutic effect of surgery and/or combination of conventional chemoradiotherapy is limited in the patients with recurrent squamous cell carcinoma (SCC) and locally advanced non-SCC of the head and neck. Currently, clinical trials of BNCT for head a
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Teruhito Aihara and Norimasa Morita
Contents 24.1 Introduction ................................................................................................................. 418 24.2 Actual State-of-the-Art Treatment ............................................................................ 418 24.2.1 Locally Advanced and Recurrent SCC ........................................................... 418 24.2.2 Non-SCC in the Head and Neck Without Malignant Melanoma.................... 418 24.3 Rationale for BNCT .................................................................................................... 418 24.3.1 18F-BPA-PET Study......................................................................................... 419 24.4 Technical Aspects and Clinical Applications ............................................................ 24.4.1 Indications for BNCT ..................................................................................... 24.4.2 Treatment Procedures...................................................................................... 24.4.3 Radiation Doses by BNCT.............................................................................. 24.5 Results 24.5.1 24.5.2 24.5.3
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......................................................................................................................... 421 Observations from Kawasaki Medical School ................................................ 421 Results obtained at Osaka University ............................................................. 422 Results from Helsinki ..................................................................................... 422
24.6 Level of Evidence......................................................................................................... 423 24.7 Further Development .................................................................................................. 423 References .............................................................................................................................
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T. Aihara (*) • N. Morita Department of Otolaryngology, Head and Neck Surgery, Kawasaki Medical School, Okayama, Japan e-mail: [email protected]; [email protected] W.A.G. Sauerwein et al. (eds.), Neutron Capture Therapy, DOI 10.1007/978-3-642-31334-9_24, © Springer-Verlag Berlin Heidelberg 2012
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T. Aihara and N. Morita
Introduction
Head and neck cancers (HNCs) account for approximately 10 % of all cancers, and about 90 % of them are squamous cell carcinoma (SCC). Surgery represents the mainstay of treatment for resectable primary site. However, the main drawback of surgery, especially for advanced T-stage cancer, is deterioration of patients’ QOL because the head and neck have many important physiological and cosmetic functions. On the other hand, the patients with unresectable cancer are candidates for radiation therapy or chemoradiotherapy. Although these therapies are effective for SCC, it is difficult to perform reradiation therapy for SCC
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