Bone marrow stem cell therapy for stroke
This book covers recent advances in all aspects of bone marrow-derived stem cells (BMSCs) for stroke treatment, while also providing comprehensive information on human clinical trials and animal models of stroke. In addition, it reviews the optimal condit
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one Marrow Stem Cell Therapy for Stroke
Bone Marrow Stem Cell Therapy for Stroke
Kunlin Jin • Xunming Ji • Qichuan Zhuge Editors
Bone Marrow Stem Cell Therapy for Stroke
Editors Kunlin Jin Department of Pharmacology Neuroscience University of North Texas Health Science Center Fort Worth, TX, USA
Xunming Ji Department of Neurosurgery, Xuanwu Hospital Capital Medical University Beijing, Beijing, China
Qichuan Zhuge Department of Neurosurgery First Affiliated Hospital Wenzhou Medical University Wenzhou, China Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research First Affiliated Hospital Wenzhou Medical University Wenzhou, China
ISBN 978-981-10-2928-8 ISBN 978-981-10-2929-5 (eBook) DOI 10.1007/978-981-10-2929-5 Library of Congress Control Number: 2016959532 © Springer Nature Singapore Pte Ltd. 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Science+Business Media Singapore Pte Ltd. The registered company address is: 152 Beach Road, #22-06/08 Gateway East, Singapore 189721, Singapore
To our families
Preface
The book Bone Marrow Stem Cell Therapy for Stroke has been created to be the primary resource for scientists, clinicians, teachers, students, and the public at large in the area of cell therapy for stroke. I am honored to have had the opportunity to edit the book with our coeditors, Qichuan Zhuge and Xunming Ji. The contributions of the editors and editorial broad cannot be overestimated. We know that stroke remains the fifth leading cause of death, with an incidence of ~700,000 events per year and a prevalence of about 4.8 million individuals, of which about 80 % are ischemic and 20 % are hemorrhagic. About one-third of these people fail to survive the event, and of the survivors, 90 % suffer permanent deficits. The most recent major advance in treatment, the use of thrombolytic agents to dissolve clots, appears to
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