Bone Marrow and Stem Cell Transplantation
The second edition of Bone Marrow and Stem Cell Transplantation expands upon the previous edition with current, detailed methods on HLA, minor-HLA and Killer Immunoglobulin Like Receptor typing. With new chapters on immunophenotyping and functional charac
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Meral Beksaç Editor
Bone Marrow and Stem Cell Transplantation Second Edition
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Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Bone Marrow and Stem Cell Transplantation Second Edition
Edited by
Meral Beksaç Department of Hematology, School of Medicine, Ankara University, Ankara, Turkey
Editor Meral Beksaç Department of Hematology School of Medicine Ankara University Ankara, Turkey
ISSN 1064-3745 ISSN 1940-6029 (electronic) ISBN 978-1-4614-9436-2 ISBN 978-1-4614-9437-9 (eBook) DOI 10.1007/978-1-4614-9437-9 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2013955604 © Springer Science+Business Media New York 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is a brand of Springer Springer is part of Springer Science+Business Media (www.springer.com)
Preface Hematopoietic stem cells have been introduced to treatment of more than 40 diseases and are being used successfully, thanks to the developments in molecular techniques and biotechnology. Recognition of the histocompatibility complex and development of immunosuppressive drugs constitute the major steps leading to almost 50,000 transplants worldwide every ye
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