Brain Chemistry and Mental Disease Proceedings of a Symposium on Bra
This volume contains the proceedings of the fourth international symposium held in November 1970 at the Texas Research Institute of Mental Sciences in Houston. Leading psychiatrists, biochemists, and pharmacologists from the United States and Great Britai
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ADVANCES IN BEHAVIORAL BIOLOGY Editorial Board: Jan Bures
Institute of Physiology, Prague, Czechoslovakia
Irwin Kopin
Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland
Bruce McEwen
Department of Biology, Rockefeller University, New York, New York
James McGaugh
Department of Psychobiology, University of California, Irvine, California
Karl Pribram
Department of Psychiatry, Stanford University School of Medicine, Stanford, California
Jay Rosenblatt
Institute of Animal Behavior, Rutgers University, Newark, New Jersey
Lawrence Welskrantz
Institute of Experimental Psychology, University of Oxford, Oxford, England
Volume 1
BRAIN CHEMISTRY AND MENTAL DISEASE Edited by Beng T. Ho and William M. Mcisaac· 1971
In preparation NEUROBIOLOGY OF THE AMYGDALA Edited by Basil E. Eleftheriou
BRAIN CHEMISTRY AND MENTAL DISEASE Proceedings of a Symposium on Brain Chemistry and Mental Disease held at the Texas Research Institute, Houston, Texas, November 18-20, 1970
Edited by Beng T. Ho and William M. Mcisaac Texas Research Institute of Mental Sciences Texas Medical Center Houston, Texas
~ PLENUM PRESS· NEW YORK-LONDON· 1971
The present volume, Volume 1 of the new series Advances in Behavioral Biology, simultaneously constitutes Volume 4 of Advances in Mental SCience, a series of proceedings of annual symposia held since 1967 at the Texas Research Institute of Mental Sciences in Houston. The preceding volumes are Congenital Mental Retardation, Drug Dependence, and Biological Aspects of Alcohol, which were published by University of Texas Press.
Library of Congress Catalog Card Number 78-165398 ISBN 978-1-4684-3059-2 001 10.1007/978-1-4684-3057-8
ISBN 978-1-4684-3057-8 (eBook)
© 1971 Plenum Press, New York Softcover reprint of the hardcover 1st edition 1971 A Division of Plenum Publishing Corporation 227 West 17th Street, New York, N. Y. 10011
United Kingdom edition published by Plenum Press, London A Division of Plenum Publishing Company, Ltd. Davis House (4th Floor), 8 Scrubs Lane, Harlesden, NW10 6SE, England All rights reserved No part of this publication may be reproduced in any form without written permission from the publisher
PREFACE This volume contains the proceedings of the fourth international symposium held in November 1970 at the Texas Research Institute of Mental Sciences in Houston. Leading psychiatrists, biochemists, and pharmacologists from the United States and Great Britain presented new material and reviewed current concepts concerning schizophrenia and the affective disorders, with particular reference to the neurochemical basis of the etiology and chemotherapy of these diseases. Although the multiple mechanisms of mental disease are still not fully understood, substantial progress has definitely been made. The greatest contribution has come through the development of new therapeutic agents that not only provide invaluable help to the mentally ill but serve as chemical tools for studying the biological mechanisms associated with the disease state. St
