Brazilian psychiatric brain bank: a new contribution tool to network studies
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Brazilian psychiatric brain bank: a new contribution tool to network studies K. C. de Oliveira • F. G. Nery • R. E. L. Ferreti • M. C. Lima • C. Cappi • ´ vila • A. T. D. L. Alho • A. Machado-Lima • L. Polichiso • L. L. Carreira • C. A H. P. Brentani • E. C. Miguel • H. Heinsen • W. Jacob-Filho • C. A. Pasqualucci B. Lafer • L. T. Grinberg
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Received: 25 February 2011 / Accepted: 22 April 2011 / Published online: 12 May 2011 Ó Springer Science+Business Media B.V. 2011
Abstract There is an urgent need for expanding the number of brain banks serving psychiatric research. We describe here the Psychiatric Disorders arm of the Brain Bank of the Brazilian Aging Brain Study Group (Psy-BBBABSG), which is focused in bipolar disorder (BD) and obsessive compulsive disorder (OCD). Our protocol was designed to minimize limitations faced by previous initiatives, and to enable designbased neurostereological analyses. The PsyBBBABSG first milestone is the collection of 10
brains each of BD and OCD patients, and matched controls. The brains are sourced from a populationbased autopsy service. The clinical and psychiatric assessments were done by an expert team including psychiatrists, through an informant. One hemisphere was perfused-fixed to render an optimal fixation for conducting neurostereological studies. The other hemisphere was comprehensively dissected and frozen for molecular studies. In 20 months, we collected
K. C. de Oliveira R. E. L. Ferreti M. C. Lima L. Polichiso L. L. Carreira ´ vila A. T. D. L. Alho W. Jacob-Filho C. A C. A. Pasqualucci L. T. Grinberg Brazilian Aging Brain Study Group (BBBABSG)/LIM 22, University of Sao Paulo Medical School, Sao Paulo, Brazil
A. Machado-Lima School of Arts, Sciences and Humanities, University of Sa˜o Paulo (EACH-USP), Sao Paulo, Brazil
K. C. de Oliveira R. E. L. Ferreti W. Jacob-Filho C. A. Pasqualucci Department of Pathology, University of Sao Paulo Medical School, Sao Paulo, Brazil
H. P. Brentani Hospital do Cancer AC Camargo, Sao Paulo, Brazil
K. C. de Oliveira F. G. Nery L. L. Carreira ´ vila B. Lafer C. A Bipolar Disorder Research Group (PROMAN), Department of Psychiatry, University of Sao Paulo Medical School, Sao Paulo, Brazil K. C. de Oliveira C. Cappi A. Machado-Lima H. P. Brentani E. C. Miguel Obsessive Compulsive Research Group (PROTOC), Department of Psychiatry, University of Sao Paulo Medical School, Sao Paulo, Brazil
M. C. Lima L. Polichiso Albert Einstein Research and Education Institute, Sao Paulo, Brazil
A. T. D. L. Alho H. Heinsen Morphological Brain Research-Unit, Wuerzburg University, Wurzburg, Germany L. T. Grinberg (&) Memory and Aging Center, Department of Neurology, UCSF, 350 Parnassus Ave, suite 905, P.O. Box 1207, San Francisco, CA 94143, USA e-mail: [email protected]
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36 brains. A final report was completed for 14 cases: 3 BDs, 4 major depressive disorders, 1 substance use disorder, 1 mood disorder NOS, 3 obsessive compulsive spectrum symptoms, 1 OCD and 1 schizophrenia. The majority were
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