Broad Cell Tropism of SADS-CoV In Vitro Implies Its Potential Cross-Species Infection Risk
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Broad Cell Tropism of SADS-CoV In Vitro Implies Its Potential CrossSpecies Infection Risk Yun Luo1,2 • Ying Chen1,2 • Rong Geng1,2 • Bei Li1 • Jing Chen1,2 • Kai Zhao1,2 • Xiao-Shuang Zheng1,2 Wei Zhang1 • Peng Zhou1 • Xing-Lou Yang1 • Zheng-Li Shi1
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Received: 15 July 2020 / Accepted: 26 October 2020 Ó Wuhan Institute of Virology, CAS 2020
Dear Editor, Swine acute diarrhoea syndrome coronavirus (SADS-CoV) is a novel swine enteric coronavirus belonged to the Coronaviridae family, Alphacoronavirus genus (Zhou P et al. 2018). The clinical signs of SADS include acute diarrhoea and vomiting, which was similar with the infection of porcine epidemic diarrhea virus (PEDV) and porcine deltacoronavirus (PDCoV) (Wang et al. 2019). The first outbreak of SADS, reported at multiple sites in Guangdong Province, China, led to the death of ten thousands of piglets (Zhou P et al. 2018). Subsequently, retrospective study demonstrated that SADS-CoV had emerged in China since August 2016 (Zhou L et al. 2018). After the devastating outbreak of SADS in January 2017, the re-emergence of SADS-CoV was reported in Fujian and Guangdong provinces in 2018 and 2019, respectively (Li et al. 2018; Zhou et al. 2019). Genome sequence analysis revealed that SADS-CoV is closely related to bat coronavirus HKU2 (Gong et al. 2017; Pan et al. 2017). The phylogenetic and haplotype network analyses showed that different SADS-CoVs occurred in Guangdong probably originated from their reservoir hosts independently (Zhou P et al. 2018). The spike (S) gene of
Yun Luo and Ying Chen authors contributed equally to this work
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12250-020-00321-3) contains supplementary material, which is available to authorized users. & Zheng-Li Shi [email protected] 1
CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety MegaScience, Chinese Academy of Sciences, Wuhan 430071, China
2
University of Chinese Academy of Sciences, Beijing 100049, China
SADS-CoV detected in Fujian shared more similarity with bat SADS-related coronaviruses (SADSr-CoVs) than other SADS-CoV strains, and more similar insertion/deletion patterns between Fujian strain and bat SADSr-CoVs were observed in genome-scale, suggesting that Fujian strain might originate from bats directly (Li et al. 2018). Our previous studies have reported that SADSr-CoVs were detected in four species of Rhinolophus bats (R. affinis, R. sinicus, R. rex, and R. pusillus) in several provinces of Southern China (Zhou P et al. 2018; Fan et al. 2019). Recently, we have identified several SADSr-CoVs in R. affinis which are closely related to the epidemic strains in pigs. These newly identified SADSr-CoVs share higher similarity ([ 99%) with SADS-CoV in S gene than those previously reported (unpublished data). These results provide further evidences that SADS-CoV remains a serious threat to swine and c
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