Burden, associated risk factors and adverse outcomes of gestational diabetes mellitus in twin pregnancies in Al Ain, UAE
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(2020) 20:612
RESEARCH ARTICLE
Open Access
Burden, associated risk factors and adverse outcomes of gestational diabetes mellitus in twin pregnancies in Al Ain, UAE Juma Alkaabi1* , Raya Almazrouei2, Taoufik Zoubeidi3, Fatema M. Alkaabi4, Fatima Rashid Alkendi5, Amel Eisa Almiri5, Charu Sharma1, Abdul-Kader Souid6, Nasloon Ali7 and Luai A. Ahmed7
Abstract Background: Gestational diabetes mellitus (GDM) in singleton pregnancies represent a high-risk scenario. The incidence, associated factors and outcomes of GDM in twin pregnancies is not known in the UAE. Methods: This was five years retrospective analysis of hospital records of twin pregnancies in the city of Al Ain, Abu Dhabi, UAE. Relevant data with regards to the pregnancy, maternal and birth outcomes and incidence of GDM was extracted from two major hospitals in the city. Regression models assessed the relationship between sociodemographic and pregnancy-related variables and GDM, and the associations between GDM and maternal and fetal outcomes at birth. Results: A total of 404 women and their neonates were part of this study. The study population had a mean age of 30.1 (SD: 5.3), overweight or obese (66.5%) and were majority multiparous (66.6%). High incidence of GDM in twin pregnancies (27.0%). While there were no statistical differences in outcomes of the neonates, GDM mothers were older (OR: 1.09, 95% CI: 1.06–1.4) and heavier (aOR: 1.02, 95% CI: 1.00 -1.04). They were also likely to have had GDM in their previous pregnancies (aOR: 7.37, 95% CI: 2.76–19.73). The prognosis of mothers with twin pregnancies and GDM lead to an independent and increased odds of cesarean section (aOR: 2.34, 95% CI: 1.03–5.30) and hospitalization during pregnancy (aOR: 1.60, 95% CI: 1.16–2.20). Conclusion: More than a quarter of women with twin pregnancies were diagnosed with GDM. GDM was associated with some adverse pregnancy outcomes but not fetal outcomes in this population. More studies are needed to further investigate these associations and the management of GDM in twin pregnancies. Keywords: Gestational diabetes mellitus, Maternal outcomes, Neonatal outcomes, Twin pregnancy
Background The prevalence of gestational diabetes mellitus (GDM) varies worldwide and among racial and ethnic groups, generally in parallel with the prevalence of type 2 diabetes. In addition, the prevalence of GDM also varies because of differences in screening practices, population * Correspondence: [email protected] 1 Department of Internal Medicine, College of Medicine, and Health Sciences, Emirates University, PO Box 17666, Al Ain, United Arab Emirates Full list of author information is available at the end of the article
characteristics, testing method, and diagnostic criteria. The prevalence of GDM has been increasing over time, likely due to increases in mean maternal age and weight, particularly increasing obesity [1–4]. GDM is a major cause for concern during pregnancy. It is associated with several adverse outcomes such as cesarean section, pre-eclampsia, macrosomia, shoulder dystocia, n
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