Calcium functioned carboxymethylated cotton fabric for hemostatic wound dressing
- PDF / 5,849,409 Bytes
- 11 Pages / 547.087 x 737.008 pts Page_size
- 32 Downloads / 215 Views
(0123456789().,-volV) ( 01234567 89().,-volV)
ORIGINAL RESEARCH
Calcium functioned carboxymethylated cotton fabric for hemostatic wound dressing Yamei Wang . Peiwen Zhou . Dongdong Xiao . Yujun Liu . Yi Zhong . Bijia Wang . Linping Zhang . Zhize Chen . Xiaofeng Sui . Xueling Feng . Hong Xu . Zhiping Mao
Received: 17 December 2019 / Accepted: 20 September 2020 Ó Springer Nature B.V. 2020
Abstract Massive hemorrhage is a frequent cause of human death in the operating room and other emergency situations. Therefore, effective hemostatic wound dressings are essential to save lives. Here we show that, calcium functioned carboxymethylated cotton fabric (MCF-Ca) conveniently prepared by carboxymethylation of cotton fabrics followed by treatment with calcium chloride solution could serve as an effective hemostatic wound dressing. The calcium content of MCF-Ca was determined as 18.11 ± 0.44 mg/g, and the calcium ions were released into a saline solution, a process that reached Y. Wang P. Zhou Y. Liu Y. Zhong B. Wang L. Zhang Z. Chen X. Sui X. Feng H. Xu (&) Z. Mao (&) Key Lab of Science and Technology of Eco-textile, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Innovation Center for Textile Science and Technology, Donghua University, No. 2999 North Renmin Road, Shanghai 201620, China e-mail: [email protected] Z. Mao e-mail: [email protected] D. Xiao Department of Urology and Andrology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China D. Xiao Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China
near-equilibrium within about 2 min. The biocompatible MCF-Ca promoted hemostasis via forming complexes with blood cells, and it showed lower blood clotting index as well as shorter blood clotting time comparing with unmodified CF in vitro. In addition, MCF-Ca exhibited better hemostatic efficiency than CF in vivo, resulting in much shorter hemostasis time and less blood loss in rat liver injury model and femoral artery animal model. In conclusion, MCF-Ca shows good potential to be used as wound dressing for patients with uncontrolled or massive hemorrhage. Keywords Calcium Hemostatic material Fabric Wound dressing
Introduction In the hospital operating room and in other emergency situations, 50% of deaths result from uncontrolled or massive hemorrhage (Bu et al. 2016; Chen et al. 2018; Lozano et al. 2012). When the wound starts bleeding, the vessels around the damage constrict physically, and platelets are activated to aggregate at the bleeding site to form thrombi that stop bleeding and prevent hemorrhage. The formed fibrin would strengthen the blood clot mechanically to promote hemostasis (Wang et al. 2018b). However, in major trauma or other emergency circumstances, it is hard to achieve hemostasis in a timely manner if the coagulation
123
Cellulose
depends solely on the body’s self-healing mechanisms. Therefore, effec
Data Loading...
