Cancer and IgE Introducing the Concept of AllergoOncology
Allergies are caused by a person’s own IgE antibodies directed against innocuous antigens like pollen or house dust mites. Interestingly, several studies have examined the relation between allergies or level of IgE and malignancies and have found an inver
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Cancer and IgE Introducing the Concept of AllergoOncology
Cancer and IgE
Manuel L. Penichet · Erika Jensen-Jarolim Editors
Cancer and IgE Introducing the Concept of AllergoOncology
Editors Manuel L. Penichet Associate Professor Division of Surgical Oncology, Department of Surgery, and Department of Microbiology, Immunology, and Molecular Genetics David Geffen School of Medicine University of California at Los Angeles (UCLA) 10833 Le Conte Avenue Los Angeles, CA 90095 USA [email protected]
Erika Jensen-Jarolim Professor and Chair Department of Pathophysiology Center of Pathophysiology, Infectiology and Immunology Medical University of Vienna Waehringer G. 18-20, 1090 Vienna, Austria [email protected]
ISBN 978-1-60761-450-0 e-ISBN 978-1-60761-451-7 DOI 10.1007/978-1-60761-451-7 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2009939537 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Cover illustration: The logo of AllergoOncology created by Dr. Erika Jensen-Jarolim and Mr. Walter Jarolim to promote the first “1st International AllergoOncology Symposium,” which took place in Vienna, Austria, on April 16, 2007. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Contents
1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Erika Jensen-Jarolim and Manuel L. Penichet 2 The Biology of IgE: Molecular Mechanism Restraining Potentially Dangerous High Serum IgE Titres In Vivo . . . . . . . Gernot Achatz, Gertrude Achatz-Straussberger, Stefan Feichtner, Sebastian Koenigsberger, Stefan Lenz, Doris Peckl-Schmid, Nadja Zaborsky, and Marinus Lamers 3 The Biology of IgE: The Generation of High-Affinity IgE Antibodies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Maria A. Curotto de Lafaille and Juan J. Lafaille 4 Epidemiological Evidence: IgE, Atopy, and Solid Tumors . . . . . Michelle C. Turner 5 Epidemiological Evidence:
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