Cancer Genome and Tumor Microenvironment
Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late ‘80s-mid ‘90s, neoplastic growth was
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Andrei Thomas-Tikhonenko Editor
Cancer Genome and Tumor Microenvironment
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Editor Andrei Thomas-Tikhonenko University of Pennsylvania Children’s Hospital of Philadelphia 3615 Civic Center Blvd. Philadelphia PA 19104 USA [email protected]
ISBN 978-1-4419-0710-3 e-ISBN 978-1-4419-0711-0 DOI 10.1007/978-1-4419-0711-0 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2009934786 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Acknowledgments
The idea to put this book together has emerged after years of thought-provoking conversations with numerous members of the cancer research community at the University of Pennsylvania and well beyond its ivied walls. I am particularly grateful to faculty and students of the CAMB512 Cancer Biology and Genetics course, which I co-directed for a number of years with Drs. Frederic Barr, Warren Pear, Martin Carroll, Costas Koumenis, and Carlo Maley. Their contributions to this volume would not show up in PubMed (save for Carlo Maley’s) but nonetheless are highly significant. Very special thanks to my assistant Kate Wurges (née Simmermon), who dealt with the contributors and their submissions with utmost patience, diligence, and can-do spirit. On the personal level, my parents, Tomas and Irina, are gratefully acknowledged for their determination to have a second-generation biologist in their household. Finally, I am indebted to my immediate family for being so understanding and supportive of this time-consuming undertaking. So, thank you Nicolas, Alexander, and Elizabeth!
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Contents
Part I
Opening Remarks
1 Hardwiring Tumor Progression . . . . . . . . . . . . . . . . . . . Andrei Thomas-Tikhonenko Part II
3
Breaking Away: Epithelial-Mesenchymal Transition
2 PI3K/AKT Pathway and the Epithelial–Mesenchymal Transition . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . A.
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