Cancer Drug Delivery Systems Based on the Tumor Microenvironment

This book proposes the importance of new systems of drug design and delivery based on cancer pathophysiology in addition to cancer molecular and cellular biology. The current studies based on molecular and cellular biology while ignoring pathoph

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ncer Drug Delivery Systems Based on the Tumor Microenvironment

Cancer Drug Delivery Systems Based on the Tumor Microenvironment

Yasuhiro Matsumura • David Tarin Editors

Cancer Drug Delivery Systems Based on the Tumor Microenvironment

Editors Yasuhiro Matsumura Division of Developmental Therapeutics, Exploratory Oncology Research & Clinical Trial Center National Cancer Center Kashiwa, Japan

David Tarin Moores UCSD Cancer Center and Department of Pathology University of California San Diego La Jolla, CA, USA

ISBN 978-4-431-56878-0    ISBN 978-4-431-56880-3 (eBook) https://doi.org/10.1007/978-4-431-56880-3 © Springer Japan KK, part of Springer Nature 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Japan KK part of Springer Nature. The registered company address is: Shiroyama Trust Tower, 4-3-1 Toranomon, Minato-ku, Tokyo 1056005, Japan

Preface

This book describes a systematic approach to the treatment of solid malignant tumors, commonly called cancers, based upon the pathophysiological properties that they all share. It focuses on the use of cytotoxic agents to destroy malignant cells without harming their healthy counterparts and assembles in one place a wide body of information that can be used in different combinations to suit the particular features of specific tumors in different patients. Other important complementary methods, namely, surgery and radiation therapy, which are valuable in the treatment of cancer patients, are beyond the scope of this book, but the methods discussed here can provide powerful adjuvant or neoadjuvant treatment options to supplement other therapeutic modalities. While much has already been written about the general topic of cancer chemotherapy, the specific advances described in this volume relate to the delivery, concentration, and retention