Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures
This book represents a comprehensive description and evaluation of the most up-to-date approaches to cancer management. Each chapter, prepared by leading basic researchers and clinicians, provides an in depth description of a specific method for cancer ma
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Cancer Growth and Progression Volume 13 Founding Editor Hans E. Kaiser† , D. Sc. Series Editors Aejaz Nasir, M.D., M.Phil., FCAP Department of Interdisciplinary Oncology-Pathology, Moffit Cancer Center & Research Institute, Tampa, FL, U.S.A. Timothy J. Yeatman, M.D. Professor of Surgery, Executive Vice President Translational Research, President & Chief Scientific Officer M2Gen, Moffit Cancer Center & Research Institute, Tampa, FL, USA
For further volumes: http://www.springer.com/series/5721
Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures
Edited by Boris R. Minev Moores UCSD Cancer Center and UCSD Division of Neurosurgery, University of California San Diego (UCSD), La Jolla, CA, USA Genelux Corporation, San Diego Science Center, San Diego, CA 92109, USA
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Editor Boris R. Minev Moores UCSD Cancer Center and UCSD Division of Neurosurgery University of California San Diego (UCSD) 3855 Health Sciences Drive 0820 92093-0820 La Jolla CA, USA and Genelux Corporation San Diego Science Center San Diego, CA 92109 USA [email protected]
ISBN 978-90-481-9703-3 e-ISBN 978-90-481-9704-0 DOI 10.1007/978-90-481-9704-0 Springer Dordrecht Heidelberg London New York © Springer Science+Business Media B.V. 2011 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Cover illustration: Tumor therapy with vaccinia virus. Mice were i.v. injected with a single dose (1 × 107 pfu per mice) of the light-emitting oncolytic vaccinia virus GLV-1h68 (row 2–4) or PBS control (row 1) 30 d after breast tumor cell implantation. Bright field photographs (left column), GFP fluorescence images (middle column), and immunohistochemical analyses of expression of GLV-1h68-encoded β-galactosidase (right column) in tumors were done 14 (row 2), 28 (row 1 and 3), and 56 d (row 4) after virus or PBS injection. Two weeks after virus injection, strong fluorescence of GFP was seen in tumors with a volume of ∼1400 mm3 . An additional 2 wk later, a much reduced GFP fluorescence was observed at tumor size of ∼480 mm3 in the same mouse. After 56 d, no GFP fluorescence was seen in the tumor which was ∼180 mm3 in size. β-galactosidase activity was detected concomitant with light emission and was completely eliminated as light emission was extinguished. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Dedicated to Professor Hans E. Kaiser, an unforgettable mentor, colleague and friend. Boris R. Minev
Contents
Part I
Chemotherapy . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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1 Plant-Derived Natural Products as Anticancer Agents . . . . . . . . David G.I. Kingston
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2 The Vinca Alkaloids . . . . . .
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