Carcinogenesis

1. Concepts on the Causal Genesis of Human Intestinal Tumors The action of chemical substances has a significant role in the genesis of human tumors. It is assumed that most human tumors are induced by exogenous chemical noxae (Schmahl, 1970;Heidelberger,

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67

Editors

E. Grundmann W. H. Kirsten Advisory Board H.-W. Altmann, K. Benirschke, A. Bohle, H. Cottier M. Eder, P. Gedigk, Chr. Hedinger, S. Iijima J. L. Van Lancker, K. Lennert, H. Meessen, B. Morson W. Sandritter, G. Seifert, S. Sell, H. C. Stoerk T. Takeuchi, H. U. Zollinger

Carcinogenesis Contributors

P. Hahn, E. Kunze, K. Nomura C. Witting, W. Schlake Editor

E. Grundmann With 112 Figures

Springer-Verlag Berlin Heidelberg New York 1979

E. Grundmann, Professor Dr., Pathologisches Institut der UniversiHit, Westring 17, D- 4400 Mtinster /Westf., Germany

ISBN-13: 978-3-642-67294-1 DOl: 10.1007/978-3-642-67292-7

e-ISBN-13: 978-3-642-67292-7

Library of Congress Cataloging in Publication Data. Main entry under title: Carcinogenesis. (Current topics in pathology; 67). Bibliography: p. Includes index. 1. Carcinogenesis. 2. Oncology, Experimental. I. Hahn, P. II. Grundmann, Ekkehard. III. Title. IV. Series. [DNLM: 1. Neoplasms-Etiology. WI CU821H v. 67 / QZ202.3 C264] RB1.E6 vol. 67 [RC268.5] 616.07'08s [616.9'94'071] 79-10558 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under § 54 of the German Copyright Law where copies are made for other than private use, a fee is payable to the publisher, the amount of the fee to be determined by agreement with the publisher.

© by Springer-Verlag Berlin Heidelberg 1979. Softcover reprint of the hardcover 1st edition 1979 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.

2122/3130 - 543210

Contents

Histogenesis of Carcinoma in the Glandular Stomach of the Rat After B I Resection. With 32 Figures • W. Schlake, K. Nomura . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

1

Morphology and Morphogenesis of Experimentally Induced Small Intestinal Tumors. With 33 Figures P. Hahn. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ..

69

Development of Urinary Bladder Cancer in the Rat. With 45 Figures E. Kunze . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

145

B-Lymphocytes in Carcinogenesis. With 2 Figures Ch. Witting. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ..

233

Subject Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ..

255

Indexed in ISR

List of Contributors

Hahn, Prof Dr. P.

Pathologisches Institut der Universitiit, Postfach 3960, Langenbeckstr. 1, 6500 Mainz, Fed. Rep. of Germany

Kunze, Priv. Doz. Dr. E.

Pathologisches Institut der Universitiit, Go~lerstr. 10, 3400 Gottingen, Fed. Rep. of Germany

Nomura, Dr. K.

Pathologisches Institut der Universitiit, Westring