Novel Apoptotic Regulators in Carcinogenesis
Our recent understanding of the cellular and molecular defects and the regulation of the apoptotic signalling pathways has resulted in rationally designed anticancer strategies and the development of novel agents that regulates apoptosis. A comprehensive
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George G. Chen • Paul B.S. Lai Editors
Novel Apoptotic Regulators in Carcinogenesis
Editors George G. Chen The Chinese University of Hong Kong Hong Kong, PR China
Paul B.S. Lai The Chinese University of Hong Kong Hong Kong, PR China
ISBN 978-94-007-4916-0 ISBN 978-94-007-4917-7 (eBook) DOI 10.1007/978-94-007-4917-7 Springer Dordrecht Heidelberg New York London Library of Congress Control Number: 2012946196 © Springer Science+Business Media Dordrecht 2012 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
During carcinogenesis, cancer cells create a permissive environment for genetic instability and accumulation of gene mutations. These alterations lead to defects in survival or death signalling pathways which enable cancer cells to continuously proliferate and grow without a proper control. Apoptosis is the major form of cell death and life control and the avoidance of apoptosis is now well known as a hallmark of cancer. Therefore, therapeutic targeting of apoptotic genes and proteins has been regarded as an attractive approach for the development of cancer therapy. In fact, most anticancer strategies currently used in clinics including chemotherapy and radiotherapy have been linked to activation of apoptotic pathways in cancer cells. However, the effi
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