Cardiac involvement at presentation in patients hospitalized with COVID-19 and their outcome in a tertiary referral hosp
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Cardiac involvement at presentation in patients hospitalized with COVID‑19 and their outcome in a tertiary referral hospital in Northern Italy Stefano Ghio1 · Enrico Baldi2,3 · Alessandro Vicentini2 · Marco Vincenzo Lenti4 · Antonio Di Sabatino4 · Angela Di Matteo5 · Valentina Zuccaro5 · Davide Piloni6 · Angelo Corsico6 · Massimiliano Gnecchi2,3 · Francesco Speciale7,8 · Anna Sabena7,8 · Luigi Oltrona Visconti1 · Stefano Perlini7,8 on behalf of San Matteo COVID Cardiac Injury Task Force Received: 13 June 2020 / Accepted: 4 September 2020 © Società Italiana di Medicina Interna (SIMI) 2020
Abstract The correlation between myocardial injury and clinical outcome in COVID-19 patients is gaining attention in the literature. The aim of the present study was to evaluate the role of cardiac involvement and of respiratory failure in a cohort of COVID-19 patients hospitalized in an academic hospital in Lombardy, one of the most affected Italian (and worldwide) regions by the epidemic. The study included 405 consecutive patients with confirmed COVID-19 admitted to a medical ward from February 25th to March 31st, 2020. Follow-up of surviving patients ended either at hospital discharge or by July 30th, 2020. Myocardial injury was defined on the basis of the presence of blood levels of hs-TnI above the 99th percentile upper reference limit. Respiratory function was assessed as PaO2/FiO2 (P/F) ratio. The primary end-point was death for any cause. During hospitalization, 124 patients died. Death rate increased from 7.9% in patients with normal hs-TnI plasma levels and no cardiac comorbidity to 61.5% in patients with elevated hs-TnI and cardiac involvement (p
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