Cardioprotective Effects of Morroniside in Rats Following Acute Myocardial Infarction
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ORIGINAL ARTICLE
Cardioprotective Effects of Morroniside in Rats Following Acute Myocardial Infarction Bangxing Yu1 and Wen Wang1,2
The aim of this study is to investigate the cardioprotective effects of morroniside in rats following acute myocardial infarction. An acute myocardial infarction (AMI) was induced by ligating the anterior descending coronary artery (LAD) [1]. Following AMI, morroniside was administered intragastrically for 24 h at doses of 45, 90, and 180 mg/kg, respectively. Biomarkers such as creatine kinase (CK-MB), lactate dehydrogenase (LDH), ɑhydroxybutyrate dehydrogenase (ɑ-HBDH), and aspartate aminotransferase (AST) activities in AMI rats in the serum were detected with commercial kits [2]. Following AMI, morroniside was administered intragastrically for 72 h at doses of 45, 90, and 180 mg/kg/d, respectively. The expression of nuclear factor kappa B (NF-κB) in cardiac myocardium was detected by western blotting analysis. Meanwhile, cardiac function was measured by echocardiography. We observed morroniside decreased the levels of CK-MB, LDH, ɑ-HBDH, and AST activities in AMI rats after 24 h. We also found that morroniside reduced the expression of NF-κB in cardiac myocardium at 72 h post AMI rats. Further, cardiac function was improved by administration of morroniside. Collectively, our findings demonstrated that morroniside had cardioprotective effects in rats following acute myocardial infarction. Attenuation of inflammation might contribute to the cardioprotective effects of morroniside.
Abstract—
KEY WORDS: morroniside; acute myocardial infarction (AMI); cardioprotection.
INTRODUCTION Acute myocardial infarction (AMI) is the leading cause of death worldwide. In China alone, there are more than 700,000 people who die from it each year. AMI occurs when there is insufficiency of blood supply to the heart and increases the myocardial necrosis. The levels of serum myocardial enzymes (CK, AST, and LDH) have been used to assess the degree of myocardial injury. The increased serum myocardial enzymes may be associated with the
1
Department of Experimental Animal Centre, XuanWu Hospital of Capital Medical University, Beijing, People’s Republic of China 2 To whom correspondence should be addressed at Department of Experimental Animal Centre, XuanWu Hospital of Capital Medical University, Beijing, People’s Republic of China. E-mail: [email protected]
occurrence of either the ischemic heart disease or acute coronary syndromes [1]. Inflammation plays not only a pivotal role in the progression of ischemic injury [2], but also a critical factor in the cardiovascular disease. Numerous anti-inflammatory drugs have been proven to be effective in attenuating myocardial injury. It has been shown that excess proinflammatory cytokines such as TNF-α and IL-6 were involved in myocardial injury, which is critically dependent on the activation of NF-κB [3]. Morroniside extracted from Cornus officinalis is one of the most abundant iridoid glycosides. It has been shown that morroniside not only ameliorates anti-
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