• PDF / 596,643 Bytes
• 9 Pages / 595.276 x 790.866 pts Page_size
• 8 Downloads / 163 Views

DOWNLOAD

REPORT

CD4+CD25+Foxp3+ Regulatory T Cells Contribute in Liver Fibrosis Improvement with Interferon Alpha L. Feng,1,2 H. Kang,2,4 L. N. Liu,2 and Y. M. Cao3

Abstract—The aim of this study is to investigate the optimal dose, treatment time, and possible immunologic mechanisms of interferon alpha (IFN-α) in the treatment of liver fibrosis. Mice were injected intraperitoneally with 10 % carbon tetrachloride to induce liver fibrosis, except in the normal control group. The experimental mice were randomly divided into four groups: physiological saline group, 20 U/gb wt IFN-α group, 40 U/gb wt IFN-α group, and 60 U/gb wt IFN-α group. After 3 and 6 weeks, type I collagen was detected in liver by hematoxylin and eosin (HE) stain, Masson’s trichrome stain, and immunohistochemical staining. The number of CD8+ T cells, the number of CD4+CD25+Foxp3+ Tregs and the activation of CD4+ T cells were detected in liver and spleen. Beneficial effects were observed in the 40 U/gb wt IFN-α group by pathological analysis. The number of CD8+ T cells in the liver was significantly lower in mice receiving middle-dose IFN-α therapy as compared to mice receiving physiological saline (P

Recommend Documents

CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential

111 11 3MB

Radiofrequency Ablation Does Not Induce the Significant Increase of CD4 + CD25 + Foxp3 + Regulatory T Cells Compared wit

159 65 482KB

Changes in Peripheral CD4+CD25 high Regulatory T Cells in the Acute-on-Chronic Liver Failure Patients with Plasma Exchan

180 3 180KB

CD4 + FOXP3 + regulatory T cells are abundantly present in inflamed muscle of patients with juvenile dermatomyositis

152 29 83KB

Shikonin Controls the Differentiation of CD4 + CD25 + Regulatory T Cells by Inhibiting AKT/mTOR Pathway

159 21 6MB

Skewed immunological balance between Th17 (CD4 + IL17A + ) and Treg (CD4 + CD25 + FOXP3 + ) cells in human oral squamous

168 45 365KB

Phenotypes and clinical significance of circulating CD4 + CD25 + regulatory T cells (Tregs) in patients with acute-on-ch

144 21 497KB

Regulatory T cells are less sensitive to glucocorticoid hormone induced apoptosis than CD4 + T cells

180 13 1MB

Active regulatory T-cells contribute to broadened T-cell repertoire diversity in ivIg-treated SLE patients

150 79 82KB

Regulatory T Cells in Inflammation

185 95 1MB

TIM-3 Genetic Variations Affect Susceptibility to Osteoarthritis by Interfering with Interferon Gamma in CD4+ T Cells

142 45 305KB

Cooperation of Liver Cells in the Process of Liver Fibrosis

175 34 1MB