Regulatory T Cells in Inflammation

Regulatory T-cells are essential components of the immune system, and several different subsets of regulatory T-cells have been described. Considerable regulatory function has been attributed to the CD4+CD25+ T-cell subset. These cells act by suppressing

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Series Editor Prof. Michael J. Parnham PhD Senior Scientific Advisor PLIVA Research Institute Ltd. Prilaz baruna Filipovic´a 29 HR-10000 Zagreb Croatia Advisory Board G. Z. Feuerstein (Merck Research Laboratories, West Point, PA, USA) M. Pairet (Boehringer Ingelheim Pharma KG, Biberach a. d. Riss, Germany) W. van Eden (Universiteit Utrecht, Utrecht, The Netherlands)

Forthcoming titles: NPY Family of Peptides in Immune Disorders, Inflammation, Angiogenesis and Cancer, G.Z. Feuerstein, Z. Zukowska (Editors), 2005 Turning up the Heat on Pain: Vanilloid Receptors in Pain and Inflammation, A.B Malmberg, K.R. Bley (Editors), 2005 Sodium Channels, Pain, and Analgesia, K. Coward, M. Baker (Editors), 2005 Complement and Kidney Disease, P.F. Zipfel (Editor), 2005 (Already published titles see last page.)

Regulatory T Cells in Inflammation

Leonie S. Taams Arne N. Akbar Marca H. M. Wauben Editors

Birkhäuser Verlag Basel · Boston · Berlin

Editors Leonie S. Taams Infection & Immunity Research Group Franklin-Wilkins Building King's College London 150 Stamford Street London SE1 9NN UK

Arne N. Akbar Department of Immunology and Molecular Pathology Division of Infection and Immunity University College London 46 Cleveland Street London W1T 4JF UK

Marca H. M. Wauben Department of Immunohematology and Blood Transfusion E3-Q, Leiden University Medical Center Albinusdreef 2, P.O. Box 9600 2300 RC Leiden The Netherlands Library of Congress Cataloging-in-Publication Data Regulatory T cells in inflammation / Leonie Taams, Arne N. Akbar, Marca H.M. Wauben, editors. p. ; cm. -- (Progress in inflammation research) Includes bibliographical references and index. ISBN 3-7643-7088-2 (alk. paper) 1. Inflammation. 2. T cells. I. Taams, Leonie. II. Akbar, Arne N. III. Wauben, Marca H. M. IV. PIR (Series) [DNLM: 1. T-Lymphocytes--immunology. 2. Immunity, Cellular. 3. Immunotherapy--methods. QW 568 R3439 2005] RB131.R44 2005 616’.0473--dc22 2004062666 Bibliographic information published by Die Deutsche Bibliothek Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data is available in the internet at http://dnb.ddb.de

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ISBN-10: 3-7643-7088-2 Birkhäuser Verlag, Basel – Boston – Berlin ISBN-13: 978-3-7643-7088-6 Birkhäuser Verlag, Basel – Boston – Berlin This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. For any