Cell-based approaches towards treating age-related macular degeneration
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MINI REVIEW
Cell-based approaches towards treating age-related macular degeneration Alireza Baradaran-Rafii . Masoumeh Sarvari . Sepideh Alavi-Moghadam . Moloud Payab . Parisa Goodarzi . Hamid Reza Aghayan . Bagher Larijani Mostafa Rezaei-Tavirani . Mahmood Biglar . Babak Arjmand
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Received: 6 January 2020 / Accepted: 5 March 2020 Ó Springer Nature B.V. 2020
Abstract Age-related macular degeneration as one of the most common causes of worldwide vision loss needs a proper approach for treatment. Therein, cell therapy and regenerative medicine can hold a great promise to be an effective approach. Accordingly, some preclinical and clinical studies were conducted to search around the therapeutic influence of stem cells in Age-related macular degeneration models and subjects. Hereupon, the purpose of the current review is to discuss the mechanisms of age-related macular A. Baradaran-Rafii Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran e-mail: [email protected] A. Baradaran-Rafii Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran M. Sarvari S. Alavi-Moghadam H. R. Aghayan B. Arjmand (&) Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism MolecularCellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran e-mail: [email protected] M. Sarvari e-mail: [email protected] S. Alavi-Moghadam e-mail: [email protected]
degeneration, appropriate animal models along with suitable dosage and route of stem cell administration for its treatment. Keywords Age-related macular degeneration Animal models Cell therapy Clinical trials Abbreviations AMD Age-related macular degeneration
M. Payab Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran e-mail: [email protected] P. Goodarzi Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran e-mail: [email protected] B. Larijani M. Biglar Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran e-mail: [email protected] M. Biglar e-mail: [email protected]
H. R. Aghayan e-mail: [email protected]
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Cell Tissue Bank
VEGF FDA BMI CCL-2 CCR-2 LIPC TIMP-3 IER-3 ESCs iPSCs MSCs RPE RPC hESCRPE SMD RP
Vascular endothelial growth factor Food and drug administration Body mass index Chemoattractant protein-2 C-C chemokine receptor-2 Hepatic lipase Tissue inhibitor of metalloproeinase-3 Immediate early response-3 Embryonic stem cells induced pluripotent stem cells Mesenchymal stem cells Retinal pigment epithelium Retinal progenitor cell Human embryonic stem cell derived retinal pigmented epithelial Stargardt’s macular dystrophy Retinal pigment
Introduction The macula luteal (an oval-formed pig
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