Cell-Based Therapy for Degenerative Retinal Disease

This book discusses why specific diseases are being targeted for cell-based retinal therapy, what evidence exists that justifies optimism for this approach, and what challenges must be managed in order to bring this technology from the laboratory into rou

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Marco A. Zarbin Mandeep S. Singh Ricardo P. Casaroli-Marano Editors

Cell-Based Therapy for Degenerative Retinal Disease

Stem Cell Biology and Regenerative Medicine Series Editor Kursad Turksen, Ph.D. [email protected]

Our understanding of stem cells has grown rapidly over the last decade. While the apparently tremendous therapeutic potential of stem cells has not yet been realized, their routine use in regeneration and restoration of tissue and organ function is greatly anticipated. To this end, many investigators continue to push the boundaries in areas such as the reprogramming, the stem cell niche, nanotechnology, biomimetics and 3D bioprinting, to name just a few. The objective of the volumes in the Stem Cell Biology and Regenerative Medicine series is to capture and consolidate these developments in a timely way. Each volume is thought-provoking in identifying problems, offering solutions, and providing ideas to excite further innovation in the stem cell and regenerative medicine fields. More information about this series at http://www.springer.com/series/7896

Marco A. Zarbin  •  Mandeep S. Singh Ricardo P. Casaroli-Marano Editors

Cell-Based Therapy for Degenerative Retinal Disease

Editors Marco A. Zarbin Institute of Ophthalmology and Visual Science Rutgers New Jersey Medical School Newark, NJ, USA

Mandeep S. Singh Wilmer Eye Institute Johns Hopkins University School of Medicine Baltimore, MD, USA

Ricardo P. Casaroli-Marano Department of Surgery School of Medicine & Hospital Clinic of Barcelona University of Barcelona Barcelona, Spain Institute of Biomedical Research Sant Pau (IIB-Sant Pau) Barcelona Tissue Bank (BST) Barcelona, Spain

ISSN 2196-8985     ISSN 2196-8993 (electronic) Stem Cell Biology and Regenerative Medicine ISBN 978-3-030-05221-8    ISBN 978-3-030-05222-5 (eBook) https://doi.org/10.1007/978-3-030-05222-5 Library of Congress Control Number: 2019931957 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been mad