Cell Killing by Reovirus: Mechanisms and Consequences
Infection of host cells by mammalian reovirus in culture or in tissues of infected animals results in cell death. Cell death of infected neurons and myocytes contributes to the pathogenesis of reovirus-induced encephalitis and myocarditis in a newborn mou
- PDF / 505,216 Bytes
- 21 Pages / 439.37 x 666.142 pts Page_size
- 92 Downloads / 183 Views
Contents 1
Introduction.......................................................................................................................... 1.1 Background on Reovirus............................................................................................ 1.2 The Reovirus Replication Cycle ................................................................................ 2 Viral Factors that Regulate Cell Death............................................................................... 2.1 Entry-Associated Cell Death Signaling...................................................................... 2.2 Virus Replication-Dependent Cell Death................................................................... 3 Role of Innate Immune Signaling in Cell Death Induction ............................................... 3.1 A Role for NF-jB and IRF3 in Reovirus-Infected Cells.......................................... 3.2 Interferon-Independent Apoptosis .............................................................................. 3.3 IFN-Dependent Necroptosis ....................................................................................... 3.4 Other Regulators of Reovirus-Induced Apoptosis ..................................................... 4 Execution of Cell Death Signaling ..................................................................................... 4.1 Death Receptor (DR) Signaling in Reovirus-Infected Cells ..................................... 4.2 Caspase-8 Activation Following Reovirus Infection ................................................. 4.3 Bcl-2 Family of Proteins and Reovirus-Induced Apoptosis...................................... 4.4 Direct Activation of Intrinsic Apoptosis by Reovirus............................................... 4.5 Additional Impacts on Mediators of Apoptosis......................................................... 4.6 Function of RIPK1 and RIPK3 Kinases for Necroptosis.......................................... 5 Impact of Cell Death on Reovirus Pathogenesis................................................................ 5.1 Cell Death and Central Nervous System Disease ..................................................... 5.2 Cell Death and Heart Disease .................................................................................... 5.3 Other Effects of Cell Death........................................................................................ 6 Impact of Cell Death on Reovirus Oncolysis..................................................................... 7 Summary and Future Directions ......................................................................................... References ..................................................................................................................................
Andrew McNamara, Katherine RoebkeâEqual Contribution. A. McNamara K. Roebke P. Danthi (&) Department of Biology, Indiana University, Bloomington, IN 47405, USA e-mail: [email protected] Current Topics in Microbiology and Immunology
Data Loading...
