Cell Nanomechanics Based on Dielectric Elastomer Actuator Device
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REVIEW
Cite as Nano-Micro Lett. (2019) 11:98 Received: 16 September 2019 Accepted: 21 October 2019 © The Author(s) 2019
https://doi.org/10.1007/s40820-019-0331-8
Cell Nanomechanics Based on Dielectric Elastomer Actuator Device Zhichao Li1, Chao Gao1, Sisi Fan1, Jiang Zou3,4, Guoying Gu3,4, Mingdong Dong5, Jie Song1,2 * Zhichao Li and Chao Gao have contributed equally to this work. * Jie Song, [email protected] Institute of Nano Biomedicine and Engineering, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, People’s Republic of China 2 Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200240, People’s Republic of China 1
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Robotics Institute, School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai 200240, People’s Republic of China State Key Laboratory of Mechanical System and Vibration, Shanghai Jiao Tong University, Shanghai 200240, People’s Republic of China Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus 8000, Denmark
HIGHLIGHTS • The main components, principle, and technology of dielectric elastomer actuator (DEA) were reviewed to illustrate that DEA can be an effective carrier for mechanobiology research. • Comparison between DEA-based bioreactors and current commercial devices is provided, as well as the outlook of the DEA bioapplications in the future. ABSTRACT As a frontier of biology, mechanobiology plays an important role in
extracellular microenvironment affect a lot in regulating the behaviors of cells such as proliferation and gene expression, etc. In such an interdisciplinary field, engineering methods like the pneumatic and motor-driven devices have been employed for years.
tion ua l a Static
but not so easy to control. Dielectric elastomer actuators (DEAs) are well known as a kind of soft actuation technology, and their research prospect in biomechanical field and fast response ( 100%)
DEA-based bioreactor
Ev
tissue and biomedical engineering. It is a common sense that mechanical cues under
pl
ic a
corresponding applications of DEAs for cellular mechanobiology research. We also
tio n
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provide a comparison between DEA-based bioreactors and current custom-built devices and share some opinions about their potential applications in the future according to widely reported results via other methods. KEYWORDS Dielectric elastomer actuator; Mechanical stimulus; Bioreactor; Mechanobiology
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1 Introduction Mechanobiology is an emerging science concern about the effects of mechanical loadings and physical forces on cell behaviors and diseases [1]. Biological cells and tissues living in vivo environment are exposed to several mechanical stimulations such as stretching and contracting. As reported so far, mechanical loadings can be sensed by cells and then influence cellular behaviors
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