Cerebral Small Vessel Disease Influences Hippocampal Subfield Atrophy in Mild Cognitive Impairment
- PDF / 688,430 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 54 Downloads / 169 Views
ORIGINAL ARTICLE
Cerebral Small Vessel Disease Influences Hippocampal Subfield Atrophy in Mild Cognitive Impairment Fennie Choy Chin Wong 1 & Chathuri Yatawara 1 & Audrey Low 1,2 & Heidi Foo 1,3 & Benjamin Yi Xin Wong 1 & Levinia Lim 1 & Brian Wang 1 & Dilip Kumar 1 & Kok Pin Ng 1,4 & Nagaendran Kandiah 1,4,5 Received: 10 May 2020 / Revised: 15 July 2020 / Accepted: 31 August 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract To investigate patterns of hippocampal subfield atrophy among patients with amnestic mild cognitive impairment, stratified by severity of small vessel disease (SVD) and corresponding associations with cognitive domains. One hundred seventy-six MCI subjects (mean age = 65.56 years, SD = 8.77) underwent neuropsychological assessments and magnetic resonance imaging. SVD was rated 0 (no SVD), 1 (mild SVD) and 2 (moderate to severe SVD) based on load of white matter hyperintensities (WMH) and lacunes. Demographics, cerebrovascular risk factors, grey and white matter volumes and hippocampal subfield atrophies were compared across SVD severity through ANCOVA analyses. Subjects were categorized into positive or negative SVDhippocampal subfield atrophy (HSA) and influence of positive SVD-HSA on episodic memory and frontal executive function was evaluated through ANCOVA analyses. All analyses corrected for covariates and bias-corrected bootstrap estimation with 1000 resamples was applied with Bonferroni correction. Hippocampal subfield atrophy worsened with increasing SVD severity. Positive SVD-HSA was characterised by significant atrophy in the subiculum, CA1, CA4, molecular layer and dentate gyrus. Greater atrophy was seen with moderate to severe SVD compared to mild SVD in these subfields. Atrophy in the five subfields of SVD-HSA was significantly associated with poor episodic memory and frontal executive function. Presence and burden of SVD influences the pattern and severity of hippocampal subfield atrophy. SVD-related hippocampal subfield atrophy is associated with poorer episodic memory and frontal executive function in mild cognitive impairment. Keywords Hippocampal subfield atrophy . Cerebral small vessel disease . Mild cognitive impairment . Alzheimer’s disease
Introduction Dementia is a neurocognitive disorder characterised by marked deterioration in multiple cognitive domains [1], affecting 40 to 50 million people worldwide [2–4], with the mixed
* Nagaendran Kandiah [email protected] 1
Department of Neurology, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore
2
University of Cambridge School of Clinical Medicine, Cambridge, UK
3
Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, Australia
4
Duke-NUS Medical School, Singapore, Singapore
5
Lee Kong Chian School of Medicine—Imperial College London, Nanyang Technological University, Singapore, Singapore
aetiology of Alzheimer’s disease (AD) and vascular pathology representing a major dementia subt
Data Loading...
