Association of tau accumulation and atrophy in mild cognitive impairment: a longitudinal study
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ORIGINAL ARTICLE
Association of tau accumulation and atrophy in mild cognitive impairment: a longitudinal study Gang Xu1,2 · Shuzhan Zheng1,2 · Zhilong Zhu1,2 · Xiaofeng Yu1,2 · Jian Jiang3 · Juanjuan Jiang1,2,5 on behalf of for the Alzheimer’s Disease Neuroimaging Initiative · Zhaohu Chu4 Received: 9 June 2020 / Accepted: 28 July 2020 © The Japanese Society of Nuclear Medicine 2020
Abstract Objective To examine the patterns of longitudinal tau accumulation and cortical atrophy and their association in subjects with mild cognitive impairment (MCI). Methods We collected 23 participants (60–89 years old, 11 males/12 females) with MCI from the Alzheimer’s Disease Neuroimaging Initiative database. All participants underwent 18F flortaucipir (FTP) positron emission tomography (PET) and structural magnetic resonance imaging (MRI) scans at the baseline and follow-up visits (12–36 months). General linear models with covariates (baseline age, sex) were used to detect brain areas of significant tau accumulation and atrophy over time. Mediation analysis was employed to explore the potential reason for sequential biomarker changes in MCI progression, adjusting for baseline age, sex, and education level. Results Voxel-wise tau accumulation in MCI subjects was predominantly located in the inferior temporal cortex, middle temporal cortex, parietal cortex, posterior cingulate, precuneus, and temporoparietal regions (P
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