Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 2: Results from
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(2020) 17:262
RESEARCH
Open Access
Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 2: Results from 108 lumbar punctures in 80 pediatric patients Sven Jarius1*†, Christian Lechner2†, Eva M. Wendel3, Matthias Baumann2, Markus Breu4, Mareike Schimmel5, Michael Karenfort6, Adela Della Marina7, Andreas Merkenschlager8, Charlotte Thiels9, Astrid Blaschek10, Michela Salandin11, Steffen Leiz12, Frank Leypoldt13, Alexander Pschibul14, Annette Hackenberg15, Andreas Hahn16, Steffen Syrbe17, Jurgis Strautmanis18, Martin Häusler19, Peter Krieg20, Astrid Eisenkölbl21, Johannes Stoffels22, Matthias Eckenweiler14, Ilya Ayzenberg23, Jürgen Haas1, Romana Höftberger24, Ingo Kleiter23,25, Mirjam Korporal-Kuhnke1, Marius Ringelstein26,27, Klemens Ruprecht28, Nadja Siebert29,30, Kathrin Schanda31, Orhan Aktas22, Friedemann Paul29,30, Markus Reindl31, Brigitte Wildemann1† and Kevin Rostásy32*†; in cooperation with the BIOMARKER study group and the Neuromyelitis optica Study Group (NEMOS)
Abstract Background: New-generation, cell-based assays have demonstrated a robust association of serum autoantibodies to full-length human myelin oligodendrocyte glycoprotein (MOG-IgG) with (mostly recurrent) optic neuritis, myelitis, and brainstem encephalitis, as well as with neuromyelitis optica (NMO)-like or acute-disseminated encephalomyelitis (ADEM)-like presentations. However, only limited data are yet available on cerebrospinal fluid (CSF) findings in MOG-IgG-associated encephalomyelitis (MOG-EM; also termed MOG antibody-associated disease, MOGAD). Objective: To describe systematically the CSF profile in children with MOG-EM. (Continued on next page)
* Correspondence: [email protected]; [email protected] † Sven Jarius and Christian Lechner shared first authorship. Brigitte Wildemann and Kevin Rostásy shared senior authorship. 1 Molecular Neuroimmunology Group, Department of Neurology, University of Heidelberg, Heidelberg, Germany 32 Department of Pediatric Neurology, Children’s Hospital Datteln, University Witten/Herdecke, Datteln, Germany Full list of author information is available at the end of the article
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