Changes in brain glucose metabolism and connectivity in somatoform disorders: an 18 F-FDG PET study
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ORIGINAL PAPER
Changes in brain glucose metabolism and connectivity in somatoform disorders: an 18F‑FDG PET study Qi Huang1 · Shuhua Ren1 · Donglang Jiang1 · Yihui Guan1 · Fang Xie1 · Daliang Sun2 · Fengchun Hua1,3 Received: 10 May 2019 / Accepted: 5 November 2019 © Springer-Verlag GmbH Germany, part of Springer Nature 2019
Abstract Somatoform disorders (SFD) are defined as a syndrome characterized by somatic symptoms which cannot be explained by organic reasons. Chronic or recurrent forms of somatization lead to heavy emotional and financial burden to the patients and their families. However, the underlying etiology of SFD is largely unknown. The purpose of this study is to investigate the changed brain glucose metabolic pattern in SFD. In this study, 18 SFD patients and 21 matched healthy controls were enrolled and underwent an 18F-FDG PET scan. First, we explored the altered brain glucose metabolism in SFD. Then, we calculated the mean 18F-FDG uptake values for 90 AAL regions, and detected the changed brain metabolic connectivity between the most significantly changed regions and all other regions. In addition, the Pearson coefficients between the neuropsychological scores and regional brain 18F-FDG uptake values were computed for SFD patients. We found that SFD patients showed extensive hypometabolism in bilateral superolateral prefrontal cortex, insula, and regions in bilateral temporal gyrus, right angular gyrus, left gyrus rectus, right fusiform gyrus, right rolandic operculum and bilateral occipital gyrus. The metabolic connectivity between right insula and prefrontal areas, as well as within prefrontal areas was enhanced in SFD. And several brain regions were associated with the somatic symptoms, including insula, putamen, middle temporal gyrus, superior parietal gyrus and orbital part of inferior frontal gyrus. Our study revealed widespread alterations of the brain glucose metabolic pattern in SFD patients. Those findings might elucidate the neuronal mechanisms with glucose metabolism and shed light on the pathology of SFD. Keywords Somatoform disorders · 18F-FDG PET · Brain connectivity · Insula · Prefrontal cortex
Introduction Qi Huang and Shuhua Ren contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00406-019-01083-0) contains supplementary material, which is available to authorized users. * Fang Xie [email protected] * Daliang Sun [email protected] * Fengchun Hua [email protected] 1
PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
2
Department of Psychiatry, Tianjin Anding Hospital, Tianjin Mental Health Center, Tianjin 300222, China
3
Department of Nuclear Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Somatoform disorders (SFD) are characterized by somatic symptoms that are either very distressing or result in significant disruption of body functioning, as well as excessive and disproportionate thoughts, feelings and
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