Identifying the characteristics of brain glucose metabolism using normal 18 F-FDG PET database in patients with temporal
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ORIGINAL ARTICLE
Identifying the characteristics of brain glucose metabolism using normal 18F-FDG PET database in patients with temporal lobe epilepsy Kun Guo 1 & Yixin Wei 2 & Menghui Yuan 2 & Longxiao Wei 2 & Jie Lu 1,3,4 Received: 17 November 2019 / Accepted: 13 April 2020 # Fondazione Società Italiana di Neurologia 2020
Abstract Objectives This study aimed to measure the global brain glucose metabolism of patients with temporal lobe epilepsy (TLE) using MIMneuro software based on the normal brain glucose metabolism database. Methods In this cross-sectional study, 23 patients (11 males and 12 females, mean age 25.6 ± 10.1 years) with TLE who underwent 18F-labeled fluoro-2-deoxyglucose positron emission tomography (18F-FDG PET) were enrolled. 18F-FDG PET images were then imported into MIMneuro software, which can automatically analyze the differences in regional brain glucose metabolism between patients and a normal database, and the results of different brain regions were presented by values of Zscore. Results In patients with TLE, 18F-FDG PET imaging showed that in addition to the presence of temporal lobe hypometabolism, there was hypometabolism in the ipsilateral hippocampus, parahippocampal gyrus, insula, amygdala, temporal operculum, and bilateral cerebellar hemisphere, while hypermetabolism was found in the contralateral temporal lobe, frontal lobe, parietal lobe, parietal lobule, angular gyrus, and precentral gyrus. There was no significant difference in brain areas between the left and the right temporal lobe seizures (P > 0.05). Conclusions We found that TLE has a specific characteristic in terms of brain glucose metabolism, and the underlying mechanism needs to be further studied that may be helpful to localize seizure focus. Keywords Temporal lobe epilepsy . 18F-FDG PET . Brain glucose metabolism . Z-score
Abbreviations SPM Statistical parametric mapping ES Epileptogenic side MTLE Mesial temporal lobe epilepsy
* Menghui Yuan [email protected] * Longxiao Wei [email protected] * Jie Lu [email protected] 1
Department of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China
2
Department of Nuclear Medicine, The Second Affiliated Hospital of Air Force Medical University, Xi’an, Shanxi, China
3
Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China
4
Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China
TLE HS ROI
Temporal lobe epilepsy Hippocampal sclerosis Region of interest
Introduction To date, epilepsy, as one of the most common brain conditions, has affected over 70 million people worldwide. It is a disorder of the brain characterized by an enduring predisposition to generate spontaneous epileptic seizures, containing several neurobiological, cognitive, and psychosocial consequences [1]. Temporal lobe epilepsy (TLE) is the most common type of the refractory focal epilepsy, and hippocampus sclerosis (HS) is the most frequent pathological finding in focal epilepsy [2]. Resection of the scleroti
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