Characteristics of Drug-Induced Liver Injury in Northeast China: Disease Spectrum and Drug Types
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ORIGINAL ARTICLE
Characteristics of Drug‑Induced Liver Injury in Northeast China: Disease Spectrum and Drug Types Chong Zhang1 · Yuyu Wu1 · Suyu Yuan1 · Xiaoguang Dou1 · Qiuju Sheng1 · Jingyan Wang1 · Wenyue Tian1 · Lan Yao1 · Yang Ding1 Received: 10 September 2019 / Accepted: 22 December 2019 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Background The aim of this study was to determine the disease spectrum and drug types causing drug-induced liver injury (DILI) in northeast China, so that the affected population can be reminded of the need to increase their post-medication monitoring. Methods A total of 470 DILI patients hospitalized at Shengjing Hospital between 2013 and 2016 were involved in this retrospective study. Results There were significant differences in the disease spectrum of the different age groups (P 10% of all drugs that caused DILI. The percentage of DILIs related to Chinese herbal medicines (CHMs) gradually increased with patient age (P = 0.002). The percentage of males taking health supplements or CHMs was significantly lower compared with females. Total bilirubin (β = 0.01, OR = 1.01, P
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