Chemical Warfare Agents: Estimating Oral Reference Doses
The FY 1993 Defense Authorization Act [Public Law (PL) 102–484, Sect. 176] directed the U.S. Department of the Army (DA) 1 to examine the scale of effort and consider plans needed to safely dispose of nonstockpile chemical materiel (NSCM), previously iden
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© Springer-Verlag 1998
Chemical Warfare Agents: Estimating Oral Reference Doses Dennis M. Opresko, Robert A. Young, Rosmarie A. Faust, Sylvia S. Talmage, Annetta P. Watson, Robert H. Ross, Kowetha A. Davidson, and Joe King Contents I. Introduction ....................................................................................................... A. Objectives ..................................................................................................... B. Approach ...................................................................................................... C. Chemical Agents of Concern ............. ......... .......................................... ....... D. Review Process ............................................................................................ II. Physical and Chemical Properties ................... ............ ..................................... A. Mustard Agents ............................................................................................ B. Nerve Agents ................................................................................................ C. Agent L (Lewisite) ....................................................................................... D. Agent CK (Cyanogen Chloride) .................................................................. III. Signs. Symptoms. and Mechanisms of Toxicity............................................. A. Mustard Agents ............................................................................................ B. Nerve Agents ................................................................................................ C. Agent L (Lewisite) ....................................................................................... D. Agent CK (Cyanogen Chloride) .................................................................. IV. Methodology for Deriving Oral Reference Doses ........................................... V. Agent HD (Sulfur Mustard) ............................................................................. A. Toxicology ................................................................................................... B. Estimated Reference Dose .................. ............................. ...................... ...... VI. Agent HT (Sulfur Mustard) .............................................................................. A. Toxicology ................................................................................................... B. Estimated Reference Dose ...........................................................................
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Communicated by George W. Ware D.M. Opresko (CBJ)· RA. Young . RA. Faust . S.S. Talmage . A.P. Watson . RH. Ross . K.A. Davidson Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37831, U.S.A. (Oak Ridge National Laboratory, managed by Lockheed Martin Energy Research Corp. for the U.S. Department of Energy under contract No. DE-AC05-960R22464) Work prepared for the U.
