Chemistry of Opioids

Recent Advances in the Synthesis of Morphine and Related Alkaloids; by N. Chida * Opioids in Preclinical and Clinical Trials; by H. Nagase and H. Fujii * Synthesis of 14-Alkoxymorphinan Derivatives and Their Pharmacological Actions; by H. Schmidhammer and

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Chemistry of Opioids

Volume Editor: Hiroshi Nagase

With Contributions by S.N. Calderon  N. Chida  H. Fujii  S. Hirono  S.M. Husbands  J.W. Lewis  K.M. Lovell  A. Lozama  H. Nagase  K.M. Prevatt-Smith  T.E. Prisinzano  H. Schmidhammer  M. Spetea  N. Yamaotsu

Editor Prof. Dr. Hiroshi Nagase Kitasato University School of Pharmaceutical Sciences Department of Medicinal Chemistry Sirokane 5-9-1 108-8641 Tokyo Minato-ku Japan [email protected]

ISSN 0340-1022 e-ISSN 1436-5049 ISBN 978-3-642-18106-1 e-ISBN 978-3-642-18107-8 DOI 10.1007/978-3-642-18107-8 Springer Heidelberg Dordrecht London New York # Springer-Verlag Berlin Heidelberg 2011 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in