Chemotherapy-induced nausea in a sample of gynaecological cancer patients: assessment issues and personal risk factors e
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ORIGINAL ARTICLE
Chemotherapy-induced nausea in a sample of gynaecological cancer patients: assessment issues and personal risk factors evaluation Valentina E. Di Mattei 1,2 & Letizia Carnelli 2,3 & Paola Taranto 2 & Martina Mazzetti 2 & Gaia Perego 3 & Sara Rottoli 2 & Paola M. V. Rancoita 4 & Alice Bergamini 5,6 & Micaela Petrone 6 & Emanuela Rabaiotti 6 & Giorgio Candotti 6 & Massimo Candiani 5,6 Received: 17 December 2019 / Accepted: 24 February 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose Chemotherapy-induced nausea (CIN) is a relevant problem for gynaecological cancer patients. The evaluation of CIN is a key aspect in its management, along with the identification of associated risk factors. The objective of the study was to compare different measurements of nausea and to investigate personal risk factors in CIN development. Method Eighty-one women treated for gynaecological cancers took part. The presence of CIN was evaluated using the MASCC Antiemesis Tool (MAT) and a patient’s report to clinicians at the subsequent chemotherapy cycle. Personal risk factors were assessed using the State-Trait Anxiety Inventory and a self-report questionnaire. Results The study shows that the agreement between patients’ assessment of CIN with MAT and what they referred to clinicians was only moderate for acute nausea (Cohen’s Kappa = 0.55; p < 0.001), while good for delayed nausea (Cohen’s Kappa = 0.68; p < 0.001). At multiple logistic regression analysis, younger age, anticipatory nausea, patient medium-high expectations of CIN, and parity emerged as risk factors for the development of acute nausea (p = 0.0087, 0.0080, 0.0122 and 0.0021, respectively). Patient medium-high expectations of CIN and being single resulted to be risk factors for delayed nausea (p = 0.0397 and 0.0024, respectively). Conclusions Our findings confirm that personal factors contribute to individual differences in the development of CIN; moreover, we highlight the importance of CIN evaluation by clinicians, underlining the need to use reliable instruments. Keywords Chemotherapy-induced nausea . Risk factors . Chemotherapy-induced nausea assessment . Gynaecological cancer
Introduction
* Letizia Carnelli [email protected] 1
School of Psychology, Vita-Salute San Raffaele University, Milan, Italy
2
Division of Clinical Neurosciences, Health Psychology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy
3
Department of Psychology, University of Milano-Bicocca, Milan, Italy
4
University Centre of Statistics in Biomedical Sciences CUSSB, Vita-Salute San Raffaele University, Milan, Italy
5
School of Medicine, Vita-Salute San Raffaele University, Milan, Italy
6
Division of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Milan, Italy
Almost 1,309,165 women worldwide suffer from gynaecological cancers; these malignancies account for the 16.5% of the total number of new cases diagnosed in 2018 [1]. Chemotherapy, combined with surgery, represents the treatment goal for these tumo
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