Chiral Recognition in Separation Methods Mechanisms and Applications

The importance of chiral interactions for both preparative and analytical separations, particularly for pharmaceutical applications, is underlined by numerous publications in this field. Here, for the first time, a team of experienced analysts from indust

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Alain Berthod Editor

Chiral Recognition in Separation Methods Mechanisms and Applications

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Editor Prof. Alain Berthod University of Lyon CNRS UMR 5180 69622 Villeurbanne Cédex France [email protected]

ISBN 978-3-642-12444-0 e-ISBN 978-3-642-12445-7 DOI 10.1007/978-3-642-12445-7 Springer Heidelberg Dordrecht London New York Library of Congress Control Number: 2010929210 © Springer-Verlag Berlin Heidelberg 2010 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Cover design: WMXDesign GmbH, Heidelberg Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

Preface

What drives a scientist to edit a book on a specific scientific subject such as chiral mechanisms in separation methods? Until December 2005, the journal Analytical Chemistry of the American Chemical Society (Washington, DC) had an A-page section that was dedicated to simple and clear presentations of the most recent techniques or the state of the art in a particular field or topic. The “A-page” section was prepared for a broad audience of chemists including industrial professionals, students as well as academics looking for information outside their field of expertise. Daniel W. Armstrong,1 one of the editors of this journal and a twenty-year+ long friend, invited me to present my view on chiral recognition mechanisms in a simple and clear way in an “A-page” article. In 2006, the “A-page” section was maintained as the first articles at the beginning of each first bi-monthly issue but the pagination was no longer page distinguished from the regular research articles published by the journal. During the time between the invitation and the submission, the A-page section was integrated into the rest of the journal and the article appeared as (2006) Anal Chem (78):2093–2099. The article was well received. John Dorsey,2 another very long time friend and colleague, invited me to present it as a lecture in his Dal-Nogare Award session of the 2008 Pittsburg Conference in New Orleans. I presented a talk focusing on the only part of chiral mechanisms that I really know and worked on: chiral recognition mechanism with the macrocyclic glycopeptide chiral selectors. Steffen Pauly, Senior Editor Chemistry for the publisher Sprin