Chlorhexidine
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Delayed-type hypersensitivity reaction in the form of oral mucositis: case report A 58-year-old man experienced delayed-type hypersensitivity reaction in the form of oral mucositis during treatment with chlorhexidine [duration of treatment to reaction onset not clearly stated]. The man presented for the assessment of an asymptomatic erythema on the anterior maxillary gingiva, which was noticed by him approximately 2 months prior to the presentation. He was a non-smoker. Based on intraoral examination, the differential diagnosis of plasma cell gingivitis or foreign body gingivitis was initially considered. His dental hygiene was good. A week after the initial examination, the erythema had progressed to the distal surface of the maxillary right first molar. He underwent an incisional biopsy under local anaesthesia. After the procedure, he was prescribed 0.20% chlorhexidine [chlorhexidine digluconate] antiseptic gel, to be applied twice daily. However, the man could not complete chlorhexidine gel treatment as he experienced an intense burning sensation immediately after its first application on the area. Based on microscopic and histopathologic findings of the tissue, a diagnosis of nonspecific mucositis was made. Anamnesis showed that he had been using 0.004% chlorhexidine based toothpaste twice daily for a few years. In the absence of other allergen, a delayed-type hypersensitivity reaction to chlorhexidine was suspected, and it was discontinued. Two weeks later, a complete resolution of his symptoms was noted without additional intervention. He was advised not to use chlorhexidine in any form. During a 4-year follow-up, he remained symptom free. Kotsailidi EA, et al. Hypersensitivity reaction of the gingiva to chlorhexidine: case report and literature review. [Review]. Oral Surgery, Oral Medicine, Oral Pathology and 803501354 Oral Radiology 130: 156-160e1, No. 2, Aug 2020. Available from: URL: http://doi.org/10.1016/j.oooo.2020.04.814
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Reactions 19 Sep 2020 No. 1822
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