Chlorhexidine/isopropyl alcohol

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Cutaneous chemical burns following off-label use: case report A preterm female neonate [exact age not stated] developed cutaneous chemical burns following off-label use of chlorhexidine/ isopropyl alcohol for skin preparation for catheterisation. The girl was born at 25 weeks of gestation via emergency caesarean section because of maternal eclampsia. Subsequently, she developed respiratory distress requiring intubation. She was scheduled for central umbilical venous and arterial catheterisation for parenteral nutrition and inotropic support, while in the neonatal unit. Hence, a skin preparation was applied using off-label topical solution of chlorhexidine/isopropyl alcohol (0.5% chlorhexidine in 70% alcohol) followed by sterile drapes over the abdomen. The procedure lasted for about 45 minutes. Her lower abdomen was noted to be erythematous after removal of the sterile drapes. An immediate plastic surgical consultation was done. Further evaluation revealed superficial and deep partial thickness burns over her lower abdomen covering 3% of the total body surface area. The burn area over the infraumbilical region was deep. The girl underwent an immediate irrigation of burn area with sodium chloride [normal saline], and the wound was conservatively managed with Moist Exposed Burn Ointment dressing every 4–6 hours. After 2 weeks, her wound healed uneventfully with scarring. Zhen LS, et al. Cutaneous Chemical Burns Associated With Chlorhexidine-Alcohol Solution in an Extremely Preterm Infant. Journal of Neonatology : 1-2, 2020. Available 803497787 from: URL: http://doi.org/10.1177/0973217920928641

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Reactions 22 Aug 2020 No. 1818