Chromatin and Disease

It is more evident now than ever before that dynamic organization of human genome into nucleoprotein structure, chromatin confers the unique regulatory mechanisms for most of the cellular phenomena, which include replication, transcription, DNA repair, re

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SUBCELLULAR BIOCHEMISTRY SERIES EDITOR J.ROBIN HARRIS, University of Mainz, Mainz, Germany

ASSISTANT EDITORS B.B. BISWAS, University of Calcutta, Calcutta, India P.QUINN, King’s College London, London, U.K Recent Volumes in this Series Volume 31

Intermediate Filaments Edited by Harald Herrmann and J. Robin Harris

Volume 32

alpha-Gal and Anti-Gal: alpha-1,3-Galactosyltransferase, alpha-Gal Epitopes and the Natural Anti-Gal Antibody Edited by Uri Galili and Jos-Luis Avila

Volume 33

Bacterial Invasion into Eukaryotic Cells Tobias A. Oelschlaeger and Jorg Hacker

Volume 34

Fusion of Biological Membranes and Related Problems Edited by Herwig Hilderson and Stefan Fuller

Volume 35

Enzyme-Catalyzed Electron and Radical Transfer Andreas Holzenburg and Nigel S. Scrutton

Volume 36

Phospholipid Metabolism in Apoptosis Edited by Peter J. Quinn and Valerian E. Kagan

Volume 37

Membrane Dynamics and Domains Edited by P.J. Quinn

Volume 38

Alzheimer’s Disease: Cellular and Molecular Aspects of Amyloid beta Edited by R. Harris and F. Fahrenholz

Volume 39

Biology of Inositols and Phosphoinositides Edited by A. Lahiri Majumder and B.B. Biswas

Volume 40

Reviews and Protocols in DT40 Research Edited by Jean-Marie Buerstedde and Shunichi Takeda

Volume 41

Chromatin and Disease Edited by Tapas K. Kundu and Dipak Dasgupta

Chromatin and Disease Subcellular Biochemistry Volume 41 Edited by

Tapas K. Kundu Jawaharlal Centre for Advanced Scientific Research, Jakkur, Bangalore, India

and

Dipak Dasgupta Saha Institute of Nuclear Physics, Kolkata, India

This series is a continuation of the journal Sub-Cellular Biochemistry. Volume 1 to 4 of which were published quarterly from 1972 to 1975

ISBN-10 ISBN-13 ISBN-10 ISBN-13

1-4020-5465-3 (HB) 978-1-4020-5465-5 (HB) 1-4020-5466-1 (e-book) 978-1-4020-5466-2 (e-book)

© 2007 Springer All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science + Business Media, Inc., 233 Springer street, New York, NY 10013, USA), except for brief excerpts in connection with review or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaption, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks and similar terms, whether or not they are subject to proprietary rights. (BS/DH) 9

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INTERNATIONAL ADVISORY EDITORIAL BOARD R. BITTMAN, Queens College, City University of New York, New York, USA D. DASGUPTA, Saha Institute of Nuclear Physics, Calcutta, India H. ENGELHARDT, Max-Planck-Institute for Biochemistry, Munich, Germany L. FLOHE, MOLISA GmbH, Magdeburg, Germany H. HERRMANN, German Cancer Research Center, Heidelberg, Germany A. HOLZENBURG, Texas A&M University, Texas, USA H-P. NASHEUER, National University of Ireland, Galway, Ireland S. ROTTEM, The Hebrew University, Jerusalem, Israel M. WYSS, DSM Nut