Chromatin Proteins Are Determinants of Centromere Function
Recent advances in the identification of molecular components of centromeres have demonstrated a crucial role for chromatin proteins in determining both centromere identity and the stability of kinetochoremicrotubule attachments. Although we are far from
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Current Topics in Microbiology and Immunology
Editors R.W. Compans, Atlanta/Georgia M. D. Cooper, Birmingham/Alabama' Y. Ito, Singapore H. Koprowski, Philadelphia/Pennsylvania F.Melchers, Basel· M. B. A. Oldstone, La Jolla/California S. Olsnes, Oslo- M. Potter, Bethesda/Maryland P. K. Vogt, La Jolla/California ' H. Wagner, Munich
Springer-Verlag Berlin Heidelberg GmbH
J. L. WORKMAN (Ed.)
Protein Complexes that Modify Chromatin With 38 Figures and 5 Tables
Springer
J.1. WORKMAN, Ph. D Howard Hughes Medical Institute Department of Biochemistry and Molecular Biology 306 Althouse Lab The Pennsylvania State University University Park PA 16802 USA
e-mail: jlw [email protected] Cover Illustration: Dividing Drosophila S2 cell (metaphase). The chromosomes are stained in green with an antibody against the Drosophila MYST-type histone acetyltransferase dMoz. dMoz is the fly homologue of the human candidate proto-oncoprotein Monocytic Leukemia Zinc Finger. The mitotic spindle appears in red (labeled with antibodies against acetylated alpha-tubulin; Sigma, St. Louis, MO). Courtesy of Dr. Thomas Kusch, Howard Hughes Medical Institute, PennState University.
ISSN 0070-217X ISBN 978-3-642-62909-9 ISBN 978-3-642-55747-7 (eBook) DOI 10.1007/978-3-642-55747-7 This work is subject to copyright. AII rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publicat ion or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in ils currenl version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. http://www.springer.de © Springer-Verlag Berlin Heidelberg 2003
Originally published by Springer-Verlag Berlin Heidelberg New York in 2003 Softcover reprint of the hardcover 1st edition 2003 Library of Congress Catalog Card Number 15-12910 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such informat ion by consulting other relevant literature. Cover Design: Design & Production GmbH, Heidelberg Typesetting: Fotosatz-Service Kiihler GmbH, Wiirzburg Production Editor: Christiane Messerschmidt, Rheinau SPIN: 10883484 27/3020 Printed on acid-free paper
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Preface
An early view of eukaryotic chromosomes was that of static structures, which stored DNA not in use within a given cell type. It was thought that packaging of DNA into higher levels of chromatin structure would suffice to repress gene exp
