Chronic hepatitis C viral infection among SLE patients: the significance of coexistence
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NOVEL ASPECTS IN LUPUS, 2017
Chronic hepatitis C viral infection among SLE patients: the significance of coexistence Naim Mahroum 1,2 & Ashraf Hejly 1,2 & Shmuel Tiosano 1,2 & Omer Gendelman 1,2 & Doron Comaneshter 3 & Arnon D. Cohen 3,4 & Howard Amital 1,2 Howard Amital
# Springer Science+Business Media New York 2017
Abstract The association between viral infection and autoimmune diseases is an established phenomenon in medicine. Hepatitis C viral infection is known to have such an association; however, its association with systemic lupus erythematosus has not been studied in a real life study driven from a large national database. The objective of this study was to investigate the association between SLE and chronic hepatitis C viral infection. Patients with SLE were compared with age- and sex-matched controls regarding the proportion chronic HCV infection. Chi-square and t tests were used for univariate analysis, and a logistic regression model was used for multivariate analysis. The study was performed utilizing the medical database of Clalit Health Services in Israel. There was a significant higher proportion of hepatitis C viral infection in SLE patients as compared to controls (1.06 and 0.39%, respectively; p < 0.001). A significant association was also observed among patients of higher socioeconomic status. In a multivariate logistic regression analysis, SLE was significantly associated with hepatitis C viral infection (OR = 2.07, 95% CI = 1.46–2.90). To conclude, Patients with SLE have a greater proportion of chronic HCV infection than matched controls. Keywords SLE . Hepatitis C . Autoimmune disease . Infections
Introduction Systemic lupus erythematosus (SLE) is a multi-systemic autoimmune disorder capable of involving more than one organ or system [1]. The variety of autoantibodies that are generated in SLE disease as well as the diversity of the clinical manifestations
* Howard Amital [email protected] 1
Department of Medicine ‘B’, Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, 5262100, Israel
2
Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel
3
Chief Physician’s Office, Clalit Health Services, Tel Aviv, Israel
4
Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel
have led many investigators to follow thoroughly patients with SLE trying to understand possible associations with other pathological disorders [2]. In recent studies, we have shown a higher proportion of patients with SLE who have had coexistent thyroid malfunction, celiac disease, and inflammatory bowel disorder as well as psychiatric involvement such as schizophrenia [3–7]. Of important value is the association of SLE with infectious diseases particularly of viral origin. This association is well described in medical literature with an emphasis on Epstein–Barr virus (EBV) infections [8–11]. The association of SLE with hepatitis B was illustrated in the study of our colleag
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