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s C Virus II Infection and Disease

Hepatitis C Virus II

Tatsuo Miyamura • Stanley M. Lemon • Christopher M. Walker • Takaji Wakita Editors

Hepatitis C Virus II Infection and Disease

Editors Tatsuo Miyamura National Institute of Infectious Diseases Tokyo, Japan

Christopher M. Walker Center for Vaccines and Immunity The Research Institute at Nationwide Children’s Hospital Columbus, Ohio USA

Stanley M. Lemon Departments of Medicine and Microbiology & Immunology The University of North Carolina Chapel Hill, North Carolina USA Takaji Wakita National Institute of Infectious Diseases Tokyo, Japan

ISBN 978-4-431-56099-9 ISBN 978-4-431-56101-9 DOI 10.1007/978-4-431-56101-9

(eBook)

Library of Congress Control Number: 2016951214 © Springer Japan 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Japan KK

Contents

Part I

Chronic Hepatitis C

Natural History of Chronic Hepatitis C . . . . . . . . . . . . . . . . . . . . . . . . . Marc G. Ghany and T. Jake Liang

3

The Multifaceted Features of HCV Infection Beyond the Liver . . . . . . . Kazuhiko Koike

57

Hepatic Fibrosis in Hepatitis C . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Melissa A. Sheiko and Hugo R. Rosen

79

Hepatocellular Carcinoma and Hepatitis C Virus . . . . . . . . . . . . . . . . . 109 Sheng-Han Wang, Shiou-Hwei Yeh, and Pei-Jer Chen HCV, Alcohol, and the Liver . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 137 Terence N. Bukong, Banishree Saha, and Gyongyi Szabo Extrahepatic Replication of HCV . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 165 Wen-Chi Su, Keigo Machida, and Michael M.C. Lai Part II

HCV Infections in Special Populations

Hepatitis C Virus Infection in Pregnancy and Childhood . . . . . . . . . . . . 187 Jessica Wen, Samantha Ohmer, and Jonathan Honegger Part III

Approaches to Therapy

Host Genetics and Responses to Antivi