Chronic Lymphocytic Leukemia Pathobiology, B Cell Receptors, Novel

This text provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for pathologists and clinical hematologists/oncologists with an interest in chronic lymphocytic leukemia. This book is designed to provide a c

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Prabhjot Kaur

Chronic Lymphocytic Leukemia Pathobiology, B Cell Receptors, Novel Mutations, Clonal Evolution

Molecular and Translational Medicine Series Editor: William B. Coleman Department of Pathology and Lab Medicine University of North Carolina School of Medicine Chapel Hill, North Carolina, USA Gregory J. Tsongalis Department of Pathology and Lab Medicine Dartmouth-Hitchcock Medical Center Lebanon, New Hampshire, USA

As we enter into this new era of molecular medicine with an expanding body of knowledge related to the molecular pathogenesis of human disease and an increasing recognition of the practical implications for improved diagnostics and treatment, there is a need for new resources to inform basic scientists and clinical practitioners of the emerging concepts, useful applications, and continuing challenges related to molecular medicine and personalized treatment of complex human diseases. This series of resource/reference books entitled Molecular and Translational Medicine is primarily concerned with the molecular pathogenesis of major human diseases and disease processes, presented in the context of molecular pathology, with implications for translational molecular medicine and personalized patient care. More information about this series at http://www.springer.com/series/8176

Prabhjot Kaur

Chronic Lymphocytic Leukemia Pathobiology, B Cell Receptors, Novel Mutations, Clonal Evolution

Prabhjot Kaur Associate Professor of Pathology Department of Pathology Dartmouth Hitchcock Medical Center and Geisel School of Medicine at Dartmouth 1 Medical Center Drive, Lebanon, 03756 New Hampshire USA

ISSN 2197-7852     ISSN 2197-7860 (electronic) Molecular and Translational Medicine ISBN 978-3-319-70602-3    ISBN 978-3-319-70603-0 (eBook) https://doi.org/10.1007/978-3-319-70603-0 Library of Congress Control Number: 2017964228 © Springer International Publishing AG 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to juris