Chronic Myeloid Leukemia Methods and Protocols
This volume highlights the molecular and cellular methods used in studying Chronic Myeloid Leukimia (CML) pathogenesis and stem cell biology. Written in the highly successful Methods in Molecular Biology series format, chapters include introduct
- PDF / 6,581,521 Bytes
- 255 Pages / 504.63 x 737.01 pts Page_size
- 27 Downloads / 286 Views
Shaoguang Li Haojian Zhang Editors
Chronic Myeloid Leukemia Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, UK
For further volumes: http://www.springer.com/series/7651
Chronic Myeloid Leukemia Methods and Protocols
Edited by
Shaoguang Li Department of Medicine Division of Hematology/Oncology University of Massachusetts Medical School Worcester, MA, USA
Haojian Zhang Medical Research Institute Wuhan University Wuhan, China
Editors Shaoguang Li Department of Medicine Division of Hematology/Oncology University of Massachusetts Medical School Worcester, MA, USA
Haojian Zhang Medical Research Institute Wuhan University Wuhan, China
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-4009-7 ISBN 978-1-4939-4011-0 (eBook) DOI 10.1007/978-1-4939-4011-0 Library of Congress Control Number: 2016943846 © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC New York
Preface Cancer stem cells are responsible for the initiation and progression of many types of cancer and are in general less sensitive to chemotherapy. There is an urgent need to fully understand the biology of cancer stem cells for developing effective therapies, and the success in this approach relies on utilizing stem cell disease models and advanced technologies to study the molecular basis of cancer stem cells. It is generally believed that human chronic myeloid leukemia (CML) is derived from an abnormal hematopoietic stem cell harboring Philadelphia chromosome that results in the formation of the BCR-ABL oncogene. Leukemia stem cells (LSCs) in CML provide an ideal cellular system for studying how LSCs survive, proliferate, and evade from treatment with tyrosine ki
Data Loading...
