Chrono-nutrition for the prevention and treatment of obesity and type 2 diabetes: from mice to men
- PDF / 513,177 Bytes
- 7 Pages / 595.276 x 790.866 pts Page_size
- 27 Downloads / 191 Views
REVIEW
Chrono-nutrition for the prevention and treatment of obesity and type 2 diabetes: from mice to men John A. Hawley 1
&
Paolo Sassone-Corsi 2
&
Juleen R. Zierath 3,4,5
Received: 4 March 2020 / Accepted: 12 June 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract The proliferation in the rate of diagnosis of obesity and type 2 diabetes mellitus continues unabated, with current recommendations for primary lifestyle changes (i.e. modification to dietary patterns) having a limited impact in reducing the incidence of these metabolic diseases. Part of the reason for the failure to alter nutritional practices is that current dietary recommendations may be unrealistic for the majority of adults. Indeed, round-the-clock access to energy-dense, nutrient-poor food makes long-term changes to dietary habits challenging. Hence, there is urgent need for innovations in the delivery of evidence-based diet interventions to rescue some of the deleterious effects on circadian biology induced by our modern-day lifestyle. With the growing appreciation that the duration over which food is consumed during a day has profound effects on numerous physiological and metabolic processes, we discuss dietary protocols that modify the timing of food intake to deliberately alter the feeding– fasting cycle. Such chrono-nutrition functions to optimise metabolism by timing nutrient intake to the acrophases of metabolic rhythms to improve whole-body insulin sensitivity and glycaemic control, and thereby positively impact metabolic health.
Keywords Chronic energy restriction . Circadian disruption . Circadian rhythm . Diet . Food . Glycaemia . Intermittent fasting . Metabolic disease . Obesity . Review . Time-restricted eating Abbreviations BMAL1 Brain and muscle ARNT-like 1 CER Chronic energy restriction
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00125-020-05238-w) contains a slide of the figure for download, which is available to authorised users. * John A. Hawley [email protected] 1
Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, VIC 3000, Australia
2
INSERM U1233-Department of Biological Chemistry, Center for Epigenetics and Metabolism, School of Medicine, University of California, Irvine, CA 92697, USA
3
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
4
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
5
Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark
CLOCK IF IGT TRF
Circadian locomotor output cycles kaput Intermittent fasting Impaired glucose tolerance Time-restricted feeding
Introduction and background The prevalence of obesity and type 2 diabetes mellitus continues to rise, with these two diseases predicted to become the biggest epidemics in history. While these conditions share some common risks (up to 80% of individuals with typ
Data Loading...
