Circadian Clocks: Role in Health and Disease
This book sheds new light on the molecular mechanisms that generate circadian rhythms. It examines how biological rhythms influence physiological processes such as sleep, hormone synthesis and secretion, immunity, kidney function, the cardiovascular syste
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Michelle L. Gumz Editor
Circadian Clocks: Role in Health and Disease
Physiology in Health and Disease
Published on behalf of The American Physiological Society by Springer
Physiology in Health and Disease This book series is published on behalf of the American Physiological Society (APS) by Springer. Access to APS books published with Springer is free to APS members. APS publishes three book series in partnership with Springer: Physiology in Health and Disease (formerly Clinical Physiology), Methods in Physiology, and Perspectives in Physiology (formerly People and Ideas), as well as general titles. More information about this series at http://www.springer.com/series/11780
Michelle L. Gumz Editor
Circadian Clocks: Role in Health and Disease
Editor Michelle L. Gumz University of Florida Gainesville Florida USA
Physiology in Health and Disease ISBN 978-1-4939-3448-5 ISBN 978-1-4939-3450-8 DOI 10.1007/978-1-4939-3450-8
(eBook)
Library of Congress Control Number: 2016930025 Springer New York Heidelberg Dordrecht London © The American Physiological Society 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)
Contents
1
Introduction to Circadian Rhythms and Mechanisms of Circadian Oscillations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . David R. Weaver
1
2
The Circadian Timing System and Endocrine Physiology . . . . . . . . Michael T. Sellix
57
3
Circadian Regulation of Sleep . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 103 Kazuo Mishima
4
The Human SCN in Health and Neuropsychiatric Disorders: Postmortem Observations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 117 Ai-Min Bao and Dick F. Swaab
5
Mammalian Circadian Clocks and Metabolism: Navigating Nutritional Challenges in a Rhythmic World . . . . . . . . . . . . . . . . . 153 Jeremy J. Stubblefie
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