Lipids in Health and Disease

Lipids are functionally versatile molecules. They have evolved from relatively simple hydrocarbons that serve as depot storages of metabolites and barriers to the permeation of solutes into complex compounds that perform a variety of signalling functions

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SUBCELLULAR BIOCHEMISTRY SERIES EDITOR J. ROBIN HARRIS, University of Mainz, Mainz, Germany

ASSISTANT EDITORS P.J. QUINN, King’s College London, London, U.K. Recent Volumes in this Series Volume 33

Bacterial Invasion into Eukaryotic Cells Tobias A. Oelschlaeger and Jorg Hacker

Volume 34

Fusion of Biological Membranes and Related Problems Edited by Herwig Hilderson and Stefan Fuller

Volume 35

Enzyme-Catalyzed Electron and Radical Transfer Andreas Holzenburg and Nigel S. Scrutton

Volume 36

Phospholipid Metabolism in Apoptosis Edited by Peter J. Quinn and Valerian E. Kagan

Volume 37

Membrane Dynamics and Domains Edited by P.J. Quinn

Volume 38

Alzheimer’s Disease: Cellular and Molecular Aspects of Amyloid beta Edited by R. Harris and F. Fahrenholz

Volume 39

Biology of Inositols and Phosphoinositides Edited by A. Lahiri Majumder and B.B. Biswas

Volume 40

Reviews and Protocols in DT40 Research Edited by Jean-Marie Buerstedde and Shunichi Takeda

Volume 41

Chromatin and Disease Edited by Tapas K. Kundu and Dipak Dasgupta

Volume 42

Inflammation in the Pathogenesis of Chronic Diseases Edited by Randall E. Harris

Volume 43

Subcellular Proteomics Edited by Eric Bertrand and Michel Faupel

Volume 44

Peroxiredoxin Systems Edited by Leopold Flohé and J. Robin Harris

Volume 45

Calcium Signalling and Disease Edited by Ernesto Carafoli and Marisa Brini

Volume 46

Creatine and Creatine Kinase in Health and Disease Edited by Gajja S. Salomons and Markus Wyss

Volume 47

Molecular Mechanisms of Parasite Invasion Edited by Barbara A. Burleigh and Dominique Soldati-Favre

Volume 48

The Coronin Family of Proteins Edited by Christoph S. Clemen, Ludwig Eichinger and Vasily Rybakin

Peter J. Quinn  Xiaoyuan Wang Editors

Lipids in Health and Disease

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Editors Peter J. Quinn King’s College London Biochemistry Department 150 Stamford Street London SE1 9NH United Kingdom [email protected]

ISBN: 978-1-4020-8830-8

Xiaoyuan Wang Jiangnan University State Key Laboratory of Food Science and Technology 1800 Lihu Avenue Wuxi 214122 China [email protected]

e-ISBN: 978-1-4020-8831-5

Library of Congress Control Number: 2008931355 # 2008 Springer ScienceþBusiness Media B.V. No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper 9 8 7 6 5 4 3 2 1 springer.com

INTERNATIONAL ADVISORY EDITORIAL BOARD R. BITTMAN, Queens College, City University of New York, New York, USA D. DASGUPTA, Saha Institute of Nuclear Physics, Calcutta, India L. FLOHE, MOLISA GmbH, Magdeburg, Germany H. HERRMANN, German Cancer Research Center, Heidelberg, Germany A. HOLZENBURG, Texas A&M University, Texas, USA H-P. NASHEUER, National University of Ireland, Galway, Ire