Circulation profile of respiratory viruses in symptomatic and asymptomatic children from Midwest Brazil
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CLINICAL MICROBIOLOGY - RESEARCH PAPER
Circulation profile of respiratory viruses in symptomatic and asymptomatic children from Midwest Brazil Italo Araujo Castro 1 & Lusmaia Damaceno Camargo Costa 2 & Anniely Carvalho Rebouças Oliveira 1 & Menira Souza 1 & Divina das Dôres de Paula Cardoso 1 & Paulo Augusto Moreira Camargos 3 & Paulo Sergio Sucasas Costa 2 & Fabiola Souza Fiaccadori 1 Received: 27 November 2019 / Accepted: 21 August 2020 # Sociedade Brasileira de Microbiologia 2020
Abstract Acute respiratory infection (ARI) is a major cause of morbidity and mortality worldwide. Most of these infections are caused by viruses. Infections pose as important triggers of acute episodes of chronic respiratory diseases (CRD). This study sought to evaluate the frequency and circulation profile of respiratory viruses among ARI symptomatic patients and completely asymptomatic children in Midwest Brazil. The study enrolled symptomatic children with and without ARI symptoms. During 1 year, 225 nasal respiratory samples were obtained from patients aged 4–14 years old. The samples were screened by multiplex nestedPCR for 16 common respiratory viruses. From 225 samples, 42 had at least one virus detected. Samples from four different patients had multiple viruses detected. The viral detection rate in symptomatic (20.1%) and asymptomatic patients (14.8%) showed no significant difference. The most frequent viruses detected were rhinovirus (28.6%), FLUA (11.9%), adenovirus (11.9%), human bocavirus (HBoV) (11.9%), and respiratory syncytial virus (RSV) antigenic group A (9.5%). Monthly detection rate was higher during the rainy season. RSVs were detected during the months with higher rainfall indexes and higher air humidity, while FLU and HBoV were detected during the winter months. The obtained results reinforce the importance of viral pathogens in pediatric population, emphasizing similar viral occurrence in symptomatic and asymptomatic children. Keywords Respiratory viruses . Asymptomatic children . Circulation profile . Multiplex PCR
Introduction Acute respiratory infections (ARI) are important causes of illness worldwide, with significant burden to public health. Responsible Editor: Mauricio Nogueira. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s42770-020-00368-0) contains supplementary material, which is available to authorized users. * Italo Araujo Castro [email protected] 1
Instituto de Patologia Tropical e Saúde Pública, Departamento de Microbiologia, Imunologia, Parasitologia e Patologia, Laboratório de Virologia Humana, Universidade Federal de Goiás, Goiânia, GO, Brazil
2
Faculdade de Medicina, Departamento de Pediatria, Universidade Federal de Goiás, Goiânia, GO, Brazil
3
Hospital Universitário, Unidade de Pediatria e Pneumologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
ARIs are frequent in all age groups and the leading cause of morbidity and mortality in young infants, especially in developing countries [1]. Among respiratory pathogens
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