Clinical and demographic parameters predict the progression from mild cognitive impairment to dementia in elderly patien
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ORIGINAL ARTICLE
Clinical and demographic parameters predict the progression from mild cognitive impairment to dementia in elderly patients Giovanni Zuliani1 · Michele Polastri2 · Tommaso Romagnoli2 · Lisa Marabini2 · Davide Seripa3 · Carlo Cervellati4 · Amedeo Zurlo2 · Angelina Passaro2 · Gloria Brombo2 Received: 8 August 2020 / Accepted: 26 August 2020 © The Author(s) 2020
Abstract Objectives To evaluate the possibility of predicting the risk of progression from mild cognitive impairment (MCI) to dementia using a combination of clinical/demographic parameters. Methods A total of 462 MCI elderly patients (follow-up: 33 months). Variable measured included cognitive functions, age, gender, MCI type, education, comorbidities, clinical chemistry, and functional status. Results Amnestic type (aMCI) represented 63% of the sample, non-amnestic (naMCI) 37%; 190 subjects progressed to dementia, 49% among aMCI, and 28% among naMCI. At Cox multivariate regression analysis, only MMSE (one point increase HR 0.84; 95% CI 0.79–0.90), aMCI (HR 2.35; 95% CI 1.39–3.98), and age (1 year increase HR 1.05; 95% CI 1.01–1.10) were independently associated with progression to dementia. A score was created based on these dichotomized variables (score 0–3): age (≥ or
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